马咪静, 杨珍珍, 尹美凤, 杨万秋, 丁梦杰, 朱利楠, 董萌, 张蕾, 李鑫, 孙振昌, 李玲, 王冠男, 张旭东, 张明智, 陈清江. 非上呼吸消化道结外NK/T细胞淋巴瘤的不良预后因素分析[J]. 中国肿瘤临床, 2018, 45(18): 939-942. DOI: 10.3969/j.issn.1000-8179.2018.18.742
引用本文: 马咪静, 杨珍珍, 尹美凤, 杨万秋, 丁梦杰, 朱利楠, 董萌, 张蕾, 李鑫, 孙振昌, 李玲, 王冠男, 张旭东, 张明智, 陈清江. 非上呼吸消化道结外NK/T细胞淋巴瘤的不良预后因素分析[J]. 中国肿瘤临床, 2018, 45(18): 939-942. DOI: 10.3969/j.issn.1000-8179.2018.18.742
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Ma Mijing, Yang Zhenzhen, Yin Meifeng, Yang Wanqiu, Ding Mengjie, Zhu Linan, Dong Meng, Zhang Lei, Li Xin, Sun Zhenchang, Li Ling, Wang Guannan, Zhang Xudong, Zhang Mingzhi, Chen Qingjiang. Analysis of adverse prognostic factors of non-upper aerodigestive tract extranodal NK/T-cell lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(18): 939-942. DOI: 10.3969/j.issn.1000-8179.2018.18.742
Citation: Ma Mijing, Yang Zhenzhen, Yin Meifeng, Yang Wanqiu, Ding Mengjie, Zhu Linan, Dong Meng, Zhang Lei, Li Xin, Sun Zhenchang, Li Ling, Wang Guannan, Zhang Xudong, Zhang Mingzhi, Chen Qingjiang. Analysis of adverse prognostic factors of non-upper aerodigestive tract extranodal NK/T-cell lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(18): 939-942. DOI: 10.3969/j.issn.1000-8179.2018.18.742
shu

非上呼吸消化道结外NK/T细胞淋巴瘤的不良预后因素分析

Analysis of adverse prognostic factors of non-upper aerodigestive tract extranodal NK/T-cell lymphoma

    摘要
  • 摘要:
      目的  分析非上呼吸消化道来源的结外NK/T细胞淋巴瘤（non-upper aerodigestive tract extranodal NK/T-cell lymphoma，NUAT-ENKTCL）的不良预后因素。
      方法  回顾性分析郑州大学第一附属医院2011年1月至2015年12月收治的20例NUAT-NKTCL患者临床资料，采用Kaplan-Meier法进行生存分析，应用Log-Rank法检验对EBER表达、年龄、性别、乳酸脱氢酶（lactic dehydrogenase，LDH）水平和治疗前外周血EBV-DNA拷贝数等进行单因素分析。
      结果  20例患者中，男女比为13:7。中位年龄为39（12~66）岁，其中≥60岁3例（15%）， < 60岁17例（85%）。Ann Arbor分期：Ⅰ、Ⅱ期8例（40%），Ⅲ、Ⅳ期12例（60%）。LDH水平升高12例（60%）。治疗前外周血EBV-DNA拷贝数增加11例（55%）。病变组织中EBER（+）13例（65%）。患者截至随访时间死亡4例，生存16例，中位总生存期（median overall survival，mOS）为15.4个月，中位无进展生存期（median progression free survival，mPFS）为8个月。完全缓解（complete response，CR）11例（55%），部分缓解（partial response，PR）5例（25%），客观缓解率（objective response rate，ORR）为80%。单因素分析显示年龄与预后呈显著相关性。
      结论  EBER的表达并不影响NUAT-ENKTCL患者的预后，年龄≥60岁患者预后较差。

     

    Abstract:
      Objective  To investigate the prognostic factors of non-upper aerodigestive tract extranodal NK/T- cell lymphoma (NUATNKTCL).
      Methods  Samples from twenty patients with NUAT-NKTCL, who were treated in The First Affiliated Hospital of Zhengzhou University between January 2011 and December 2015, were collected. The overall survival (OS) and progression-free survival (PFS) time of these patients were estimated by the Kaplan-Meier method. Through the log-rank test, the survival curves were compared among EBER expression, age, lactate dehydrogenase (LDH) level, EBV-DNA copies, and gender.
      Results  The male-female ratio of patients was 13:7. The median age was 39 years (range 12-66), with 3 patients above 60 years (15%) and the others below 60 years (85%). Forty percent of the patients were Ann-Arbor stage Ⅰ/Ⅱ and 60% of them were Ann-Arbor stage Ⅲ/Ⅳ. Twelve patients (60%) had a high level of LDH. Eleven patients had a high level of EBV-DNA copies in peripheral blood (55%) before treatment. Thirteen patients were EBER positive. Among the 20 patients, 4 patients died and 16 survived. The median OS was 15.4 months, and the median PFS was 8 months. Eleven patients received CR, 5 achieved PR while the ORR was 80%. The Log-rank test showed a significant association between age and prognosis (P=0.001).
      Conclusions  There was no correlation between EBER expression and prognosis of NUAT-NKTCL. Patients over 60 years of age had a poor prognosis.

     

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