Abstract:
Objective To investigate the factors affecting the relapse and prognosis of rhabdomyosarcoma (RMS) in children.
Methods The clinical and pathological data of 91 patients with RMS between January 2000 and October 2017 in Tianjin Medical University Cancer Hospital were retrospectively analyzed. The single-factor chi-square test or Fisher's exact probability test and Logistic regression analysis were used to analyze the risk factors affecting RMS relapse. The prognostic factors of patients with recurrent RMS were assessed using Kaplan-Meier analysis and the Cox risk model.
Results The RMS recurrence rate was 41.8%. The 1-, 3-, and 5-year survival rates in the recurrent group were 97.4%, 52.9%, and 27.8%, respectively. The clinical stage, risk grouping, development of metastasis, and administration of standard chemotherapy were risk factors for RMS recurrence, among which the administration of standard chemotherapy was an independent risk factor for relapse (P < 0.05). Survival analysis showed that the time to relapse and development of metastasis were associated with the prognosis of recurrent patients, and these were both independent factors (P < 0.05).
Conclusions Standard chemotherapy helps reduce the recurrence rate of RMS. The time to relapse and development of metastasis are associated with the prognosis of recurrent patients.