Abstract:
Objective To evaluate the safety and efficacy of transurethral enucleation of bladder tumor(TUEBT) in the treatment of non muscle-invasive bladder cancer (NMIBC).
Methods The clinical and pathological data of 82 NMIBC patients treated between November 2015 and January 2018 in the First Affiliated Hospital of the Jinzhou Medical University were retrospectively analyzed. The 82 NMIBC patients were divided into a TUEBT group (38 cases) and a transurethral resection of bladder tumor (TURBT) group (44 cases). The differences in intraoperative indices, postoperative indices, and pathological staging between the two groups were compared.
Results The bladder irrigation, indwelling catheter, and postoperative hospitalization times in the TUEBT group were (21.00±3.55) h, (4.34±0.81) d, and (5.29±0.96) d, respectively, compared with (27.57±3.87) h, (5.32±0.83) d, and (6.32±0.86) d in the TURBT group, and the differences between groups were statistically significant (P < 0.05). The operative time in the TUEBT group (29.55±4.13) min was longer than in the TURBT group (25.30±4.01) min. The hemoglobin decrease in the TUEBT group (2.00±0.38) g/dL was less than that in the TURBT group (2.30±0.32) g/dL. The incidence of obturator nerve reflex in the TUEBT group was 13.16% (5/38), compared to 34.09% (15/44) in the TURBT group. The recurrence rate in the TUEBT group was 10.53% (4/38), compared to 29.55% (13/44) in the TURBT group. The detrusor deletion rate in the TUEBT group was 0 (0/38), compared to 31.82% (14/44) in the TURBT group. The repeat transurethral resection (ReTUR) standard was met in 22 cases in the TUEBT group and 33 in the TURBT group. ReTUR due to lack of a detrusor was required in 0 cases in the TUEBT group and 14 in the TURBT group. The differences in the above clinical characteristics were statistically significant (P < 0.05).
Conclusions TUEBT can remove a tumor completely, while preserving the detrusor, improving the accuracy of pathological staging, and reducing the probability of ReTUR. For NMIBC, TUEBT can obtain satisfactory clinical efficacy, with surgical safety and long-term efficacy superior to those of TURBT.