浸润性乳腺癌X线影像学表现与其分子分型的相关性研究

刘静; 季宇; 李芳芳; 曹阳; 刘佩芳

doi:10.3969/j.issn.1000-8179.2018.20.902

浸润性乳腺癌X线影像学表现与其分子分型的相关性研究

Relationship between mammographic features and molecular subtypes in invasive breast cancer patients

摘要

摘要:
目的探讨浸润性乳腺癌X线影像学表现与其分子分型的相关性。
方法收集2016年1月至2016年3月182例天津医科大学总医院及天津医科大学肿瘤医院的女性乳腺癌患者临床病理资料, 均经手术后病理证实为浸润性乳腺癌, 且术前行乳腺X线影像检查。采用BI-RADS分类标准对图像进行析, 依据2013年St.Gallen会议专家共识对浸润性乳腺癌进行乳腺癌分子分型, 分析乳腺X线影像表现与浸润性乳腺癌分子分型的相关性。
结果乳腺癌分子分型与乳腺X线影像钙化表现具有相关性(V=0.221, P < 0.05), 其中三阴性乳腺癌(18/20)相较于Luminal A型(12/20)、Luminal B型(80/132)及HER-2过表达型(4/10)多表现为非钙化型病变(P < 0.05)。相较于非Luminal型乳腺癌(1/16), Luminal型乳腺癌(30/85)的肿块型病变多表现为边缘毛刺(P < 0.05)。
结论浸润性乳腺癌的X线影像表现与其分子分型具有一定的相关性。

Abstract:
Objective To assess the relationship between mammographic features and molecular subtypes in invasive breast cancer patients.
Methods We performed a retrospective review of mammographic images from a total of 182 histopathologically diagnosedbreast cancer patients treated in Tianjin Medical University General Hospital and Tianjin Medical University Cancer Institute and Hospital between January 2016 and March 2016.Mammographic features were assessed according to the Breast Imaging Reporting and Data System(BI-RADS).Molecular subtypes were classified according to the St Gallen International Expert Consensus.Statistical analysis was performed to assess the correlation between mammographic features and molecular subtypes of breast cancer.
Results There was a relationship between mammographic calcifications and molecular subtypes of invasive breast cancer (V=0.221, P < 0.05).In comparison with Luminal A (12/20), Luminal B (80/132), and HER-2 enriched (4/10) breast cancers, most triple-negative breast cancers (18/ 20) were non-calcified lesions (P < 0.05).The proportion of spiculated masses was higher in Luminal breast cancer (30/85) than in nonLuminal breast cancer (1/16) (P < 0.05).
Conclusions There is a relationship between mammographic features and molecular subtypes of invasive breast cancer.

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