Abstract:
Objective To assess the relationship between mammographic features and molecular subtypes in invasive breast cancer patients.
Methods We performed a retrospective review of mammographic images from a total of 182 histopathologically diagnosedbreast cancer patients treated in Tianjin Medical University General Hospital and Tianjin Medical University Cancer Institute and Hospital between January 2016 and March 2016.Mammographic features were assessed according to the Breast Imaging Reporting and Data System(BI-RADS).Molecular subtypes were classified according to the St Gallen International Expert Consensus.Statistical analysis was performed to assess the correlation between mammographic features and molecular subtypes of breast cancer.
Results There was a relationship between mammographic calcifications and molecular subtypes of invasive breast cancer (V=0.221, P < 0.05).In comparison with Luminal A (12/20), Luminal B (80/132), and HER-2 enriched (4/10) breast cancers, most triple-negative breast cancers (18/ 20) were non-calcified lesions (P < 0.05).The proportion of spiculated masses was higher in Luminal breast cancer (30/85) than in nonLuminal breast cancer (1/16) (P < 0.05).
Conclusions There is a relationship between mammographic features and molecular subtypes of invasive breast cancer.