张婧, 薛丽, 党雅梅, 赵凤辉, 李红玲. NQO1和HO-1在T细胞淋巴瘤中的表达及意义[J]. 中国肿瘤临床, 2018, 45(20): 1033-1037. DOI: 10.3969/j.issn.1000-8179.2018.20.920
引用本文: 张婧, 薛丽, 党雅梅, 赵凤辉, 李红玲. NQO1和HO-1在T细胞淋巴瘤中的表达及意义[J]. 中国肿瘤临床, 2018, 45(20): 1033-1037. DOI: 10.3969/j.issn.1000-8179.2018.20.920
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Zhang Jing, Xue Li, Dang Yamei, Zhao Fenghui, Li Hongling. Expression and significance of NAD (P) H:quinone oxidoreductase 1 and heme oxygenase-1 proteins in T-cell lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(20): 1033-1037. DOI: 10.3969/j.issn.1000-8179.2018.20.920
Citation: Zhang Jing, Xue Li, Dang Yamei, Zhao Fenghui, Li Hongling. Expression and significance of NAD (P) H:quinone oxidoreductase 1 and heme oxygenase-1 proteins in T-cell lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(20): 1033-1037. DOI: 10.3969/j.issn.1000-8179.2018.20.920
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NQO1和HO-1在T细胞淋巴瘤中的表达及意义

Expression and significance of NAD (P) H:quinone oxidoreductase 1 and heme oxygenase-1 proteins in T-cell lymphoma

    摘要
  • 摘要:
      目的   探讨醌氧化还原酶1NAD(P)H:quinine oxidoreductase 1, NQO1与血红素加氧酶-1(heme oxygenase-1, HO-1)在T细胞淋巴瘤(T-cell lymphoma, TCL)中的表达及其临床病理特征间的关系。
      方法  回顾性分析2012年12月至2018年5月甘肃省人民医院确诊的61例TCL患者的临床资料。采用免疫组织化学法检测NQO1和HO-1在61例TCL组织(TCL组)及20例淋巴结反应性增生组织(对照组)中的表达水平。
      结果  NQO1和HO-1在TCL组织中的阳性表达率均明显高于淋巴结反应性增生组织, 差异具有统计学意义(P < 0.05);NQO1与TCL临床分期和B症状有关(P < 0.05);HO-1与TCL的临床分期、骨髓侵犯和B症状密切相关(P < 0.05);二者与TCL患者的年龄、性别、乳酸脱氢酶水平及病理分型无关(P>0.05);NQO1和HO-1的表达存在相关性(r=0.264;P=0.040)。
      结论  NQO1和HO-1在TCL中高表达, 可能互相作用参与TCL的发生发展。

     

    Abstract:
      Objective  To investigate the expression of NAD (P) H:quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) in Tcell lymphoma (TCL), and investigate the correlation between these two indicators and other clinicopathological parameters in TCL.
      Methods  Clinical data of 61 patients with TCL who were initially diagnosed in Gansu Provincial Hospital were analyzed retrospectively. Immunohistochemical examination was performed to detect NQO1 and HO-1 expression levels in 61 TCL tissues (TCL group) and 20 lymph node reactive hyperplasia tissues (control group).
      Results  Positive expression rates of NQO1 and HO-1 were significantly higher in TCL tissues than in lymph node reactive hyperplasia tissues (P < 0.05).NQO1 expression was closely related with Ann-Arbor clinical stage and B symptoms (P < 0.05); HO-1 expression was correlated with clinical stage, bone marrow invasion, and B symptoms (P < 0.05). NQO1 and HO-1 expression levels were not related to age, sex, lactate dehydrogenase level, and pathological type (P>0.05); there was a correlation between NQO1 and HO-1 expression (r=0.264; P=0.040).
      Conclusions  NQO1 and HO-1 are highly expressed in TCL and may interact and contribute to the occurrence and development of TCL.

     

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