mRNA疗法在肿瘤免疫治疗中的应用

潘燕平; 张昊; 向虹; 阳小胡; 胡勇

doi:10.3969/j.issn.1000-8179.2019.03.246

mRNA疗法在肿瘤免疫治疗中的应用

doi: 10.3969/j.issn.1000-8179.2019.03.246

中国科学院深圳先进技术研究院，合成生物学研究所，定量合成生物学研究中心（广东省深圳市 518055）

基金项目:

深圳市海外高层次人才创新创业专项资金 KQTD20170331160605510

详细信息

作者简介:
潘燕平专业方向为mRNA基因治疗及肿瘤的细胞免疫治疗研究。E-mail:925391180@qq.com

通讯作者:
胡勇, yong.hu@siat.ac.cn

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- 文章访问数: 177
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- 被引次数: 0
出版历程
- 收稿日期: 2018-12-10
- 修回日期: 2019-01-23
- 刊出日期: 2019-02-15

Application of mRNA in tumor immunotherapy

Centre for Quantitative Synthetic Biology, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Funds:

Shenzhen Special Fund for Overseas High-level Talent Innovation and Entrepreneurship Program KQTD20170331160605510

More Information

Corresponding author: Yong Hu. E-mail:yong.hu@siat.ac.cn

摘要

摘要: mRNA疗法以mRNA为制剂治疗疾病，是一种新兴的基因疗法，既可通过功能性蛋白的表达治疗基因缺陷性疾病或组织修复，又可通过抗原或抗体或受体的表达应用于免疫治疗，具有极大的应用价值。在肿瘤免疫治疗中，编码肿瘤相关抗原、特异性抗原、抗体或受体的mRNA进入细胞质后翻译成蛋白质，进而诱导特定免疫反应，实现疾病的预防与治疗。随着免疫治疗技术和mRNA的技术发展，针对恶性肿瘤和传染性疾病等的mRNA免疫治疗已步入临床应用阶段。本文将就mRNA的合成、纯化及修饰，基于mRNA的肿瘤免疫疗法、临床试验结果及开发新药所遇到的关键性机遇与挑战进行综述。
- mRNA /
- 肿瘤疫苗 /
- 肿瘤免疫治疗 /
- 临床应用
Abstract: mRNA therapy, which involves the use of mRNAs as drugs for disease treatment, is a new kind of gene therapy. It can either treat diseases caused by gene deficiency or repair tissue through the expression of functional proteins, or be applied to immunotherapy through the expression of antigens, antibodies, or receptors, and is thus, of great value for various clinical applications. In tumor immunotherapy, mRNA that encodes tumor-related antigens, or specific antigens, antibodies, or receptors enters the cytoplasm and is translated into proteins, which then induce specific immune responses, thereby enabling disease prevention and treatment. With the development of immunotherapy and mRNA technologies, mRNA therapy for malignant tumors and infectious diseases has entered the stage of clinical applications. This review briefly introduces the synthesis, purification, and modification of mRNA, with emphasis on mRNA-based tumor immunotherapy, clinical trial results, and key opportunities and challenges in the development of new drugs.
- mRNA /
- tumor vaccine /
- tumor immunotherapy /
- clinical application

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