外周血sPD-L1在小细胞肺癌患者化疗期间变化及其临床意义

田浩; 康晓艳; 杨琳; 朱海波; 郭伟; 宋霞

doi:10.3969/j.issn.1000-8179.2019.09.272

外周血sPD-L1在小细胞肺癌患者化疗期间变化及其临床意义

doi: 10.3969/j.issn.1000-8179.2019.09.272

田浩^①,,
康晓艳^②,
杨琳^①,
朱海波^①,
郭伟^③,
宋霞^③, ,

①.
山西医科大学（太原市030001）
②.
山西省肿瘤医院放疗科（太原市030001）
③.
山西省肿瘤医院呼吸二科（太原市030001）

基金项目:

山西省应用基础研究面上自然基金项目 201701D121093

详细信息

作者简介:
田浩专业方向为肺部肿瘤临床治疗。E-mail：123412179@qq.com

通讯作者:
宋霞 songxia76@hotmail.com

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- 文章访问数: 63
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- 被引次数: 0
出版历程
- 收稿日期: 2019-03-07
- 修回日期: 2019-04-15
- 刊出日期: 2019-05-15

Change of peripheral blood sPD- L1 during chemotherapy in patients with small cell lung cancer and its clinical significance

Tian Hao^{①
,},
Kang Xiaoyan^②,
Yang Lin^①,
Zhu Haibo^①,
Guo Wei^③,
Song Xia^{③
, ,}

①.
Shanxi Medical University, Taiyuan 030001, China
②.
Department of Radiotherapy, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China
③.
No.2 Department of Respiratory Medicine, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China

Funds:

the Natural Fund for Applied Basic Research in Shanxi Province 201701D121093

More Information

Corresponding author: Xia Song; E-mail:songxia76@hotmail.com

摘要

摘要: 目的肿瘤微环境中，免疫相关机制使程序性死亡分子配体1（programmed death ligand 1，PD-L1）表达上调，从而异常激活PD-L1信号通路，介导肿瘤免疫逃逸。可溶性程序性死亡配体1（soluble programmed death ligand 1，sPD-L1）是PD-L1的一种存在形式。有研究证实sPD-L1在肺鳞癌及腺癌中的表达与疾病进展相关，而小细胞肺癌（small cell lung cancer，SCLC）恶性程度高侵袭性强，相关研究较少。本研究旨在观察sPD-L1在SCLC患者血浆中的表达变化及临床意义。方法筛选2018年3月至2018年11月山西省肿瘤医院经病理学检查诊断为SCLC的初治患者94例作为试验组，选取同期健康体检者17例作为对照组，比较两组血浆sPD-L1的动态变化，并分析sPD-L1表达与TNM分期、远处转移以及胃泌素释放肽前体（pro-gastrin-releasing peptide，ProGRP）的相关性。结果 SCLC组血浆sPD-L1水平高于健康人组（P < 0.05和P < 0.01）。疾病缓解期的SCLC患者化疗后血浆sPD-L1水平比化疗前显著降低（P < 0.01）；疾病进展期患者化疗后血浆sPD-L1水平比化疗前显著升高（P < 0.01）。SCLC患者sPD-L1异常高表达与疾病进展显著相关（P < 0.05）。血浆sPD-L1表达与肿瘤标志物ProGRP呈正相关。结论 SCLC患者外周血浆sPD-L1的表达较健康人增高，且与疗效密切相关。
- 小细胞肺癌 /
- 可溶性程序性死亡配体1 /
- PD-L1表达
Abstract: Objective In tumor microenvironment, immune-related mechanisms up-regulate the expression of programmed death ligand 1 (PD-L1), which abnormally activates PD-L1 signaling pathway and mediates tumor immune escape. Soluble programmed death ligand 1 (sPD-L1) is a form of PD-L1. It has been confirmed that the expression of sPD-L1 in lung squamous cell carcinoma and adenocarcinoma is related to disease progression, while small cell lung cancer (SCLC) has a high degree of malignancy, strong invasiveness and few related studies. The purpose of this study was to observe the changes in expression of sPD-L1 in the plasma of SCLC patients and their clinical significance. Methods A total of 94 patients with SCLC diagnosed by pathological examination in Shanxi Provincial Cancer Hospital from March 2018 to November 2018 were selected as test group, and 17 healthy persons in the same period were selected as control group. The dynamic changes of plasma sPD-L1 were compared between the two groups, and the correlations among the expression of sPD-L1 and TNM stage, distant metastasis, and pro-gastrin-releasing peptide (ProGRP) was analyzed. Results The level of sPD-L1 in the test group was higher than that in the control group (P < 0.05 and P < 0.01, respectively). In patients with SCLC in the remission stage, the serum sPD-L1 level after chemotherapy was significantly lower than that before chemotherapy (P < 0.01); in patients with advanced stage, the serum sPD-L1 level after chemotherapy was significantly higher than that before chemotherapy (P < 0.01). The abnormal high expression of sPD-L1 in SCLC patients was significantly correlated with the progression of the disease (P < 0.05). The expression of sPD-L1 in serum was positively correlated with the tumor marker ProGRP. Conclusions The expression of sPDL1 in peripheral plasma of patients with SCLC is higher than that in healthy individuals and is closely related to the clinical effect.
- small cell lung cancer (SCLC) /
- soluble programmed death ligand 1 (sPD-L1) /
- programmed death ligand 1 (PD-L1) expression

HTML全文

图 1 sPD-L1浓度与OD₄₅₀值之间线性关系

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图 2 外周血sPD-L1表达水平

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图 3 SCLC患者治疗期间sPD-L1变化趋势

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图 4 SCLC患者治疗期间ProGRP变化趋势

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表 1 SCLC患者化疗过程中外周血中sPD-L1水平的变化

表 2 SCLC患者化疗前后外周血中ProGRP水平的变化

表 3 sPD-L1与SCLC患者临床特征的相关性

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