林达佳, 吴健生, 薛芳沁, 陈林昊, 曾长青. 体质量指数对结直肠癌切除术中淋巴结检测数目的影响[J]. 中国肿瘤临床, 2019, 46(16): 822-826. DOI: 10.3969/j.issn.1000-8179.2019.16.458
引用本文: 林达佳, 吴健生, 薛芳沁, 陈林昊, 曾长青. 体质量指数对结直肠癌切除术中淋巴结检测数目的影响[J]. 中国肿瘤临床, 2019, 46(16): 822-826. DOI: 10.3969/j.issn.1000-8179.2019.16.458
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Lin Dajia, Wu Jiansheng, Xue Fangqin, Chen Linhao, Zeng Changqing. Effect of body mass index on the number of lymph nodes harvested in patients who underwent colorectal cancer resection[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(16): 822-826. DOI: 10.3969/j.issn.1000-8179.2019.16.458
Citation: Lin Dajia, Wu Jiansheng, Xue Fangqin, Chen Linhao, Zeng Changqing. Effect of body mass index on the number of lymph nodes harvested in patients who underwent colorectal cancer resection[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(16): 822-826. DOI: 10.3969/j.issn.1000-8179.2019.16.458
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体质量指数对结直肠癌切除术中淋巴结检测数目的影响

Effect of body mass index on the number of lymph nodes harvested in patients who underwent colorectal cancer resection

    摘要
  • 摘要:
      目的  探讨体质量指数（body mass index，BMI）对结直肠癌切除术淋巴结检测数目的影响。
      方法  回顾性分析自2014年12月至2017年1月福建省立医院收治的328例结直肠癌患者的临床病理资料，全部患者均行结直肠癌切除术，以术后病理的淋巴结检测数目为依据分为两组（< 12枚组与≥ 12枚组），将各组的临床病理因素进行统计学分析。
      结果  单因素分析显示，患者的BMI（χ2=7.697，P=0.006）、肿瘤部位（χ2=7.900，P=0.048），肿瘤TNM分期（χ2=34.795，P < 0.010）等因素在两组间的淋巴结检测数目方面差异具有统计学意义；Logistic回归分析提示，根据世界卫生组织（WHO）标准（正常值范围：18.5~24.9 kg/m2）对BMI进行分组，BMI ≥ 25 kg/m2组与BMI < 25 kg/m2组相比，淋巴结检测数目 < 12枚的风险显著增加（OR=2.557，95% CI：1.231~5.309；P=0.012）。肿瘤位于直肠、乙状结肠的患者与其他部位患者相比，淋巴结检测数目 < 12枚的风险显著增加（OR=1.731，95% CI：1.066~2.810；P=0.027）。
      结论  高BMI指数可影响结直肠癌手术中是否获取足够的淋巴结检测数目，进而影响其术后病理分期。

     

    Abstract:
      Objective  To analyze the effect of body mass index (BMI) on the number of lymph nodes (LNs) harvested in patients who underwent colorectal cancer resection.
      Methods  A retrospective analysis of 328 patients with colorectal cancer who were treated at Fujian Provincial Hospital between December 2014 and January 2017 was conducted. All patients underwent colorectal cancer resection and were assigned into 2 groups: < 12-LN group and ≥ 12-LN group. Potential clinicopathological variables that might influence the number of LNs harvested were statistically analyzed.
      Results  Univariate analyses demonstrated that BMI (χ2=7.697, P=0.006), tumor location (χ2=7.900, P=0.048), and TNM stage (χ2=34.795, P < 0.01) affected the number of LNs harvested. Logistic regression analysis revealed that BMI of ≥ 25 kg/m2 and rectosigmoid location were associated with 2.557-and 1.731-fold increases in the number of LNs harvested, compared with BMI < 25 kg/m2 group and other tumor locations, respectively.
      Conclusions  Higher BMI may decrease the number of LNs harvested in patients who underwent colorectal cancer resection and could affect the postoperative pathological stage.

     

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