史文, 王海江. 50例胃结直肠双原发癌临床病理特征分析[J]. 中国肿瘤临床, 2019, 46(16): 841-844. DOI: 10.3969/j.issn.1000-8179.2019.16.524
引用本文: 史文, 王海江. 50例胃结直肠双原发癌临床病理特征分析[J]. 中国肿瘤临床, 2019, 46(16): 841-844. DOI: 10.3969/j.issn.1000-8179.2019.16.524
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Shi Wen, Wang Haijiang. Clinical and pathological features of 50 cases of double primary cancer in the stomach and colorectum[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(16): 841-844. DOI: 10.3969/j.issn.1000-8179.2019.16.524
Citation: Shi Wen, Wang Haijiang. Clinical and pathological features of 50 cases of double primary cancer in the stomach and colorectum[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(16): 841-844. DOI: 10.3969/j.issn.1000-8179.2019.16.524
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50例胃结直肠双原发癌临床病理特征分析

Clinical and pathological features of 50 cases of double primary cancer in the stomach and colorectum

    摘要
  • 摘要:
      目的  探讨胃、结直肠双原发癌（double primary cancers，DPC）临床特点。
      方法  回顾性分析新疆医科大学附属肿瘤医院2015年6月至2018年12月收治的50例胃、结直肠DPC患者的临床资料，分析其发病年龄、性别、肿瘤分期和病理类型等情况。其中，同时性双原发癌（synchronous carcinoma，SC）30例，异时性双原发癌（metachronous carcinoma，MC）20例，分组进行统计学分析。
      结果  胃、结直肠DPC发病年龄为（65.44±11.94）岁，其中男性37例，女性13例，男女比为2.85：1；肿瘤病理分期以Ⅱ~Ⅲ期为主（47/50，94.0%）；病理类型以腺癌为主（35/50，70.0%）。MC患者第一原发癌与第二原发癌在病理类型、分化程度及分期等因素相比较均无显著性差异（P < 0.05），SC患者诊断年龄较SC患者更大（68.87±8.83）岁vs.（60.30±14.22）岁，P=0.011。SC与MC在性别、TNM分期、病理类型、分化程度、吸烟、饮酒状态方面均无显著性差异（P < 0.05）。
      结论  临床工作中应重点加强对年龄≥ 50岁的胃癌或结直肠癌患者开展第二原发癌的筛查。

     

    Abstract:
      Objective  To discuss the clinical and pathological features of double primary cancer (DPC) in the stomach and colorectum.
      Methods  The data of 50 patients who were diagnosed with DPC and underwent surgery at The Affiliated Tumor Hospital of Xinjiang Medical University between June 2015 and June 2018 were retrospectively analyzed. The data that were analyzed included the age of onset, gender ratio, tumor stage, pathological type, and other characteristics. Thirty patients had synchronous DPC (SC), and 20 had metachronous DPC (MC). Statistical analysis was performed in the two groups.
      Results  The mean age was (65.44±11.94) years with 37 men and 13 women. The ratio of men to women was 2.85:1. The tumor-node-metastasis (TNM) stages were mainly stages Ⅱ-Ⅲ (47/50, 94.0%). The pathological pattern was mainly adenocarcinoma (35/50, 70.0%). There was no significant difference in the pathological type, differentiation degree, and tumor stage between the first and second primary cancers in patients with MC (P < 0.05). The age of patients diagnosed with SC was older than that of patients diagnosed with MC(68.87±8.83) years vs. (60.30±14.22) years (P=0.011). SC and MC showed no differences in gender, TNM stage, pathological type, differentiation degree, and smoking and alcohol consumption status.
      Conclusions  Screening for second primary cancer should be strengthened over the age of 50 years for patients with gastric cancer or colorectal cancer.

     

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