闫风彩, 李鑫宝, 林育林, 余春开, 周全, 李雁. 卵巢来源腹膜假黏液瘤临床病理分析[J]. 中国肿瘤临床, 2019, 46(17): 887-890. DOI: 10.3969/j.issn.1000-8179.2019.17.584
引用本文: 闫风彩, 李鑫宝, 林育林, 余春开, 周全, 李雁. 卵巢来源腹膜假黏液瘤临床病理分析[J]. 中国肿瘤临床, 2019, 46(17): 887-890. DOI: 10.3969/j.issn.1000-8179.2019.17.584
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Yan Fengcai, Li Xinbao, Lin Yulin, Yu Chunkai, Zhou Quan, Li Yan. Clinicopathological analysis of ovarian pseudomyxoma peritonei[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(17): 887-890. DOI: 10.3969/j.issn.1000-8179.2019.17.584
Citation: Yan Fengcai, Li Xinbao, Lin Yulin, Yu Chunkai, Zhou Quan, Li Yan. Clinicopathological analysis of ovarian pseudomyxoma peritonei[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(17): 887-890. DOI: 10.3969/j.issn.1000-8179.2019.17.584
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卵巢来源腹膜假黏液瘤临床病理分析

Clinicopathological analysis of ovarian pseudomyxoma peritonei

    摘要
  • 摘要:
      目的  探讨卵巢来源腹膜假黏液瘤（pseudomyxoma peritonei，PMP）的临床病理学特征及免疫组织化学表型。
      方法  回顾性分析2010年1月至2019年1月272例于首都医科大学附属北京世纪坛医院确诊为PMP患者的临床资料，研究PMP肿瘤来源，复阅病理切片并行免疫组织化学标记，标记抗体包括CK7、CK20、CEA、Villin、CDX2、SATB2、CA125、ER、PR、PAX8、MUC1、MUC2等。
      结果  272例PMP中阑尾来源245例（90.1%）、非阑尾来源27例（9.9%）。卵巢来源PMP仅5例（1.8%），其中4例为黏液性囊腺瘤、1例为交界性黏液性囊腺瘤，均发生在单侧，5例中2例合并成熟性囊性畸胎瘤；腹膜播散肿瘤中2例为无细胞性黏液、2例为低级别腹膜黏液癌、1例为高级别腹膜黏液癌。免疫组织化学法检测显示，5例PMP患者组织中CK20、CEA、Villin、CDX2均阳性，2例黏液性囊腺瘤合并畸胎瘤患者的SATB2部分阳性、2例SATB2阴性、1例SATB2灶状阳性。
      结论  卵巢来源PMP罕见，需对阑尾全部取材或对可疑组织块行连续切片，以排除阑尾黏液性肿瘤，并结合临床症状体征、影像学表现、手术所见、组织学特征及免疫组织化学法检测进行综合分析。

     

    Abstract:
      Objective  To analyze the clinicopathological characteristics of ovarian pseudomyxoma peritonei (PMP).
      Methods  Clinical and pathological data from a total of 272 PMP patients diagnosed at Beijing Shijitan Hospital from January 2010 to January 2019 were collected from a database and retrospectively analyzed to study the origin of PMP tumors. Pathological slides marked with antigens were further studied using immunohistochemical staining, including CK7, CK20, CEA, Villin, CDX2, SATB2, CA125, ER, PR, MUC1, and MUC2.
      Results  Among the 272 PMP patients studied, the tumors of 245 (90.1%) originated from the appendix, while the remaining 27 (9.9%) originated from non-appendix tissues, including 5 (1.8%) from the ovaries. Ovarian cases included two ovarian teratomas, two ovarian mucinous cystadenomas, and one borderline ovarian mucinous cystadenoma. Histopathological analysis of peritoneal metastases further revealed two acellular mucins, two low-grade mucinous carcinoma peritonei, and one high-grade mucinous carcinoma peritonei, while immunohistochemistry revealed positive staining for CK20, CEA, Villin, and CDX2; SATB2 was also found to be partially positive in teratomas with mucinous tumors:negative in two cases and partially positive in one case.
      Conclusions  The occurrence of ovarian PMP is rare. Its precise diagnosis demands for a serial section of the whole appendix or suspected tissue to exclude any appendiceal mucinous neoplasms, as well as the combination of a comprehensive analysis of its clinical signs and symptoms, imaging findings, surgical findings, histopathological characteristics, and immunohistochemistry.

     

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