Abstract:
Objective To investigate the correlation between metabolic syndrome (MetS) and gastric cancer risk and its clinicopathological features.
Methods This retrospective study included 808 patients with histologically diagnosed gastric cancer from Tianjin Medical University Cancer Institute and Hospital between February 2011 and June 2013 and 1, 146 randomly healthy controls. The collected data comprised clinical characteristics and laboratory test results.
Results The triglyceride (TG) level and hypertension incidence were higher and high density lipoprotein cholesterol (HDL-C) level was lower in patients with gastric cancer than in healthy controls. The positivity rate of MetS in patients with gastric cancer was significantly higher than that in healthy controls19.1% vs. 9.6%; OR=2.535(1.805-3.562) and was associated with gastric cancer riskfemale:OR=1.514 (1.197-2.390), male:OR=2.683(1.798-4.004). In male patients, high body mass indexBMI, hypertension, and diabetes mellitus were important risk factors of gastric cancer. In female patients, low HDL-C level, hypertension, and diabetes were associated with an increased risk of gastric cancer. Compared with healthy controls, patients who met all the diagnostic criteria of MetS, including high BMI and TG levels, low HDL-C level, hypertension, and diabetes mellitus, had an increased OR for gastric cancer. MetS was related to poorly differentiated cancer, advanced T and N stages, and TNM stages.
Conclusions Patients with gastric cancer has higher frequency of MetS. MetS-related diseases were more common in patients with poorly differentiated and advanced TNM stages, suggesting that metabolic disorder plays an important role in the occurrence and development of gastric cancer.