梁晓峰, 李利娟, 刘俊田. 代谢综合征与胃癌发病风险及临床病理特征相关性的研究[J]. 中国肿瘤临床, 2019, 46(19): 986-993. DOI: 10.3969/j.issn.1000-8179.2019.19.090
引用本文: 梁晓峰, 李利娟, 刘俊田. 代谢综合征与胃癌发病风险及临床病理特征相关性的研究[J]. 中国肿瘤临床, 2019, 46(19): 986-993. DOI: 10.3969/j.issn.1000-8179.2019.19.090
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Liang Xiaofeng, Li Lijuan, Liu Juntian. A case control study of the correlation between metabolic syndrome and gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(19): 986-993. DOI: 10.3969/j.issn.1000-8179.2019.19.090
Citation: Liang Xiaofeng, Li Lijuan, Liu Juntian. A case control study of the correlation between metabolic syndrome and gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(19): 986-993. DOI: 10.3969/j.issn.1000-8179.2019.19.090
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代谢综合征与胃癌发病风险及临床病理特征相关性的研究

A case control study of the correlation between metabolic syndrome and gastric cancer

    摘要
  • 摘要:
      目的  探讨代谢综合征（metabolic syndrome，MetS）与胃癌发病风险及其临床病理特征的相关性。
      方法  回顾性分析2011年2月至2013年6月天津医科大学肿瘤医院经病理确诊的808例胃癌患者的病例情况、术前检查及临床病理资料，同时选取1 146例随机对照者，分析其Mets与临床病理特征相关性。
      结果  与对照组相比，所有胃癌患者甘油三酯（triglyceride，TG）水平较高，高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）水平较低，高血压发病率较高。胃癌患者MetS阳性率显著高于对照组（19.1% vs.9.6%）。MetS的发生与胃癌发病风险相关总体：OR=2.535（1.805~3.562），女性：OR=1.514（1.197~2.390），男性：OR=2.683（1.798~4.004）。MetS包含的各个代谢因素异常均能提高胃癌患者的发病风险，包括高身体质量指数（body mass in-dex，BMI）及TG、低HDL-C、高血压和糖尿病。在男性胃癌患者中，高BMI、高血压和糖尿病是胃癌发病风险升高的重要因素；在女性胃癌患者中，低HDL-C、高血压和糖尿病与胃癌发病风险增加密切相关。MetS与低分化腺癌，较晚的T、N分期及TNM分期相关。
      结论  本研究胃癌患者MetS及其包含的各项代谢相关因素异常率均高于对照组，并且在低、未分化和进展期胃癌患者中MetS相关的代谢异常更为多见，提示代谢紊乱可能在胃癌发生发展中发挥一定作用。

     

    Abstract:
      Objective  To investigate the correlation between metabolic syndrome (MetS) and gastric cancer risk and its clinicopathological features.
      Methods  This retrospective study included 808 patients with histologically diagnosed gastric cancer from Tianjin Medical University Cancer Institute and Hospital between February 2011 and June 2013 and 1, 146 randomly healthy controls. The collected data comprised clinical characteristics and laboratory test results.
      Results  The triglyceride (TG) level and hypertension incidence were higher and high density lipoprotein cholesterol (HDL-C) level was lower in patients with gastric cancer than in healthy controls. The positivity rate of MetS in patients with gastric cancer was significantly higher than that in healthy controls19.1% vs. 9.6%; OR=2.535(1.805-3.562) and was associated with gastric cancer riskfemale:OR=1.514 (1.197-2.390), male:OR=2.683(1.798-4.004). In male patients, high body mass indexBMI, hypertension, and diabetes mellitus were important risk factors of gastric cancer. In female patients, low HDL-C level, hypertension, and diabetes were associated with an increased risk of gastric cancer. Compared with healthy controls, patients who met all the diagnostic criteria of MetS, including high BMI and TG levels, low HDL-C level, hypertension, and diabetes mellitus, had an increased OR for gastric cancer. MetS was related to poorly differentiated cancer, advanced T and N stages, and TNM stages.
      Conclusions  Patients with gastric cancer has higher frequency of MetS. MetS-related diseases were more common in patients with poorly differentiated and advanced TNM stages, suggesting that metabolic disorder plays an important role in the occurrence and development of gastric cancer.

     

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