Abstract:
Objective To evaluate the efficacy of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal carcinomatosis of epithelial ovarian cancer (EOCPC).
Methods From May 2004 to May 2019, 186 patients with advanced ovarian cancer underwent surgery at Beijing Shijitan Hospital. Of them, 133 patients met the selection criteria after propensity score matching:80 patients who had undergone CRS (control group) and 53 patients who had undergone CRS+HIPEC (study group). We performed subgroup analysis. The primary endpoints were to compare the median overall survival (mOS) between the two groups.
Results The mOS in the study group was significantly longer than that in the control group (87.3 months vs. 25.2 months, P=0.002). The 5-year survival rate in the study group was 2.5 times than that in the control group (46.5% vs. 18.3%, P=0.003), and the 3-and 4-year survival rates were both 1.9 times than those in the control group (70.0% vs. 36.7%, P=0.016). On subgroup analysis, the mOS in the study group was found to be significantly longer than that in the control group both in patients with complete CRS (118.1 months vs. 70.7 months, P=0.024) and in those with incomplete CRS (87.3 months vs. 23.1 months, P=0.028).
Conclusions Standardized CRS+HIPEC, as a necessary measure for the treatment of EOCPC, has significant survival benefits.