Abstract:
Objective To detect and evaluate the importance of the BRAF V600E gene mutation in ultrasound-guided fine needle aspiration biopsies (FNA) for the diagnosis of benign and malignant thyroid nodules.
Method Totally, 121 patients who were admitted to the hospital for the first time between January 2018 and June 2018 were included in this study. Cytological diagnosis and evaluation of 130 thyroid nodules from these patients were performed for detecting the BRAF V600E gene mutation.
Results Among the 130 nodules screened, 120 were postoperative pathological papillary carcinoma and 10 were benign. The analysis of the BRAF V600E gene mutation combined with FNA increased the sensitivity of cytological diagnosis from 81.7% to 92.5% (P < 0.05). The difference was statistically significant.
Conclusions BRAF V600E gene mutation detection combined with FNA can effectively improve the sensitivity and accuracy of diagnosis of benign and malignant thyroid nodules and has greater potential than traditional and simple cytological diagnostic methods.