杨姣姣, 李志平. 肾细胞癌立体定向体部放疗的研究进展[J]. 中国肿瘤临床, 2019, 46(23): 1233-1236. DOI: 10.3969/j.issn.1000-8179.2019.23.087
引用本文: 杨姣姣, 李志平. 肾细胞癌立体定向体部放疗的研究进展[J]. 中国肿瘤临床, 2019, 46(23): 1233-1236. DOI: 10.3969/j.issn.1000-8179.2019.23.087
Yang Jiaojiao, Li Zhiping. Progress of research on stereotactic body radiation therapy for the treatment of renal cell carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(23): 1233-1236. DOI: 10.3969/j.issn.1000-8179.2019.23.087
Citation: Yang Jiaojiao, Li Zhiping. Progress of research on stereotactic body radiation therapy for the treatment of renal cell carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(23): 1233-1236. DOI: 10.3969/j.issn.1000-8179.2019.23.087

肾细胞癌立体定向体部放疗的研究进展

Progress of research on stereotactic body radiation therapy for the treatment of renal cell carcinoma

  • 摘要: 肾细胞癌(renal cell carcinoma,RCC)传统上被认为是放射治疗抵抗性肿瘤,手术是原发性RCC的标准治疗手段。因高龄及临床并发症丧失手术机会的患者,可通过立体定向体部放疗(stereotactic body radiation therapy,SBRT)提高RCC局部控制(local control,LC)率,并显示较好的疗效。SBRT结合图像引导放疗(image-guided radiation therapy,IGRT)技术实现靶区的精确定位,对周围正常组织损伤小,具有LC率高、毒性低并可延长无法手术患者生存期等优点。因SBRT应用于RCC的LC率、不良反应以及生存期等结果,根据机器及放射剂量的不同而有所变化,本文将就SBRT应用于转移性和原发性RCC的研究进展进行综述。

     

    Abstract: Renal cell carcinoma (RCC) is considered to be resistant to radiotherapy; consequently, surgery is still the standard treatment for local RCC. However, patients who can not undergo surgery due to advanced age or medical complications can be treated with stereotactic body radiation therapy (SBRT). SBRT has been shown to improve the local control (LC) rate in patients with RCC. In combination with image-guided radiation therapy, SBRT can be applied to the precise target area, thereby causing little damage to the surrounding normal tissues. Additionally, SBRT has the advantages of a high LC rate and low toxicity and can prolong the survival of patients ineligible for surgery. Consequently, the LC rate, adverse reactions, and survival of patients with RCC undergoing SBRT vary depending on the machine and radiation dose. Here, we will review the progress of research on SBRT for the treatment of patients with primary and metastatic RCC.

     

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