Abstract: As one of the most common malignant tumors, breast cancer seriously threatens women's lives and health. Strengthening science popularization, screening, and reasonable and effective preventive measures are important preventive measures for groups at high-risk for breast cancer. At present, the main preventive measures include advocating good lifestyle habits, reasonable preventive drugs, and surgical resection. Although the preventive effects of drugs and surgery are better, they are not easily accepted by those at high-risk for breast cancer due to adverse reactions such as drug toxicity, postoperative appearance changes, and psychological factors. The establishment of reasonable preventive measures has become a breakthrough point for the prevention of breast cancer in high-risk groups. This can not only reduce the risk of breast cancer in this group but also reduce unnecessary medical consumption. This can benefit patients and save social resources. This article will review the research progress on preventive measures for groups at high-risk for breast cancer.