张冬洁, 付芬芬, 谢凌铎, 褚福涛, 万琪婷, 解云涛. BRCA1/2突变的中国健康女性乳腺预防性切除及Ⅰ期重建的临床实践[J]. 中国肿瘤临床, 2020, 47(1): 34-38. DOI: 10.3969/j.issn.1000-8179.2020.01.429
引用本文: 张冬洁, 付芬芬, 谢凌铎, 褚福涛, 万琪婷, 解云涛. BRCA1/2突变的中国健康女性乳腺预防性切除及Ⅰ期重建的临床实践[J]. 中国肿瘤临床, 2020, 47(1): 34-38. DOI: 10.3969/j.issn.1000-8179.2020.01.429
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Dongjie Zhang, Fenfen Fu, Lingduo Xie, Futao Chu, Qiting Wan, Yuntao Xie. Clinical practice of prophylactic nipple- sparing mastectomy and immediate reconstruction in Chinese healthy women with BRCA1/BRCA2 germline mutation[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2020, 47(1): 34-38. DOI: 10.3969/j.issn.1000-8179.2020.01.429
Citation: Dongjie Zhang, Fenfen Fu, Lingduo Xie, Futao Chu, Qiting Wan, Yuntao Xie. Clinical practice of prophylactic nipple- sparing mastectomy and immediate reconstruction in Chinese healthy women with BRCA1/BRCA2 germline mutation[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2020, 47(1): 34-38. DOI: 10.3969/j.issn.1000-8179.2020.01.429
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BRCA1/2突变的中国健康女性乳腺预防性切除及Ⅰ期重建的临床实践

Clinical practice of prophylactic nipple- sparing mastectomy and immediate reconstruction in Chinese healthy women with BRCA1/BRCA2 germline mutation

    摘要
  • 摘要:
      目的  探讨对携带BRCA1/2突变的中国健康女性实施乳腺预防性切除及I期重建的可行性。
      方法  选择2018年1月至2019年2月3例于北京大学国际医院就诊的携带BRCA1/2突变的中国健康女性，其中2例携带BRCA1突变、1例携带BRCA2突变，均有乳腺癌家族史，年龄为34~36岁，实施预防性保留乳头-乳晕的双侧乳腺切除和Ⅰ期假体重建术。
      结果  3例患者术后无并发症发生，术后中位随访时间为18个月，均无乳腺癌发生，对重建乳房外形满意，且焦虑和恐惧情绪显著下降，取得良好的疗效。
      结论  对携带BRCA1/2突变且有乳腺癌家族史的中国健康女性，在严格筛选的基础上，可慎重开展乳腺预防性切除及Ⅰ期重建术。

     

    Abstract:
      Objective  To explore the possibility of prophylactic nipple-sparing mastectomy and immediate reconstruction in healthy Chinese women with BRCA1/BRCA2 germline mutation.
      Methods  From January 2018 to February 2019, three healthy Chinese women with a BRCA1/BRCA2 germline pathogenic mutation were treated at the Department of Breast Surgery, Peking University International Hospital (2 cases of BRCA1 mutation and 1 case of BRCA2 mutation); these three women (aged 34-36 years) had a strong family history of breast cancer. Thus, they underwent prophylactic nipple-sparing mastectomy and immediate reconstruction.
      Results  The operations were successfully completed, and no complications occurred. After a median 18-month follow-up, no breast cancer occurred in the three women; they were satisfied with the reconstructed breast's shape, and their anxiety also significantly reduced.
      Conclusions  Healthy Chinese women with a BRCA1/BRCA2 germline mutation and a strong family history of breast cancer can possibly consider prophylactic nipple-sparing mastectomy and immediate reconstruction as options.

     

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