tsRNAs与肿瘤关系的研究进展

何小雪; 樊希蕊; 黄芸; 王辉

doi:10.3969/j.issn.1000-8179.2020.02.197

tsRNAs与肿瘤关系的研究进展

doi: 10.3969/j.issn.1000-8179.2020.02.197

何小雪^①,,
樊希蕊^①,
黄芸^①,
王辉^{①, ②, ,}

①.
昆明医科大学附属延安医院消化内科(昆明市 650051)
②.
云南省肿瘤免疫防治研究重点实验室(昆明市 650051)

基金项目:

本文课题受国家自然科学基金项目 No.81860424

详细信息

作者简介:
何小雪专业方向为消化道疾病的研究。E-mail:hxxcq2@163.com

通讯作者:
王辉. E-mail:weihool@126.com

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- 文章访问数: 99
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- 被引次数: 0
出版历程
- 收稿日期: 2019-10-03
- 刊出日期: 2020-01-30

Advances in research on the relationship between tsRNAs and tumors

Xiaoxue He^{①
,},
Xirui Fan^①,
Yun Huang^①,
Hui Wang^{①, ②
, ,}

①.
Department of Gastroenterology, The Affiliated Yan An Hospital of Kunming Medical University, Kunming 650051, China
②.
Key Laboratory of Tumor ImmunologicalPrevention and Treatment of Yunnan Province, Kunming 650051, China

Funds:

This work was supported by the National Natural Science Foundation of China No.81860424

More Information

Corresponding author: Hui Wang, E-mail:weihool@126.com

摘要

摘要: 转运RNA（transfer RNA，tRNA）衍生的小RNAs（transfer RNA-derived small RNAs，tsRNAs）是来源于成熟tRNA或tRNA前体的一类新兴的非编码单链RNAs，主要包括tRNA衍生片段（tRNA-derived RNA fragments，tRFs）和tRNA半分子（tRNA halves，tiRNAs）两类。tsRNAs在多种肿瘤中存在差异性表达，并且影响肿瘤的增殖、侵袭或转移过程，尽管其背后的机制尚未完全阐明，但有成为肿瘤新的生物标志物及治疗靶点的潜力。本文对tsRNAs与常见肿瘤的关系进行综述，以期为肿瘤的诊断、治疗及预防提供新思路。
- tsRNAs /
- tRNA衍生片段 /
- tRNA半分子 /
- 肿瘤
Abstract: Transfer RNA-derived small RNAs (tsRNAs) are an emerging class of non-coding single-stranded RNA that are derived from mature transfer RNA (tRNA) or tRNA precursors. They primarily consist of tRNA-derived RNA fragments (tRFs) and tRNA halves (tiRNAs). Studies have confirmed that tsRNAs are differentially expressed in a variety of tumors and involved in tumor processes including proliferation, invasion, and metastasis. Although the underlying mechanisms have not been fully elucidated, tsRNAs have the potential to be new biomarkers and therapeutic targets for tumors. This review provides an overview of the relationship between tsRNAs and common tumors to provide new ideas for the diagnosis, treatment, and prevention of tumors.
- tsRNAs /
- tRFs /
- tiRNAs /
- tumors

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