Advances in studies on the relationship between Aurora kinases and gastrointestinal tumors
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摘要: Aurora激酶是一类高度进化保守的丝/苏氨酸激酶,包括Aurora-A、Aurora-B、Aurora-C亚型,在细胞周期中呈动态分布,通过调控细胞有丝分裂过程中中心体的成熟和分离、双极纺锤体组装和稳定、染色体精确分离及细胞质有效分裂等过程,确保细胞周期正常完成。近年来研究者已在人体多种实体瘤中发现Aurora激酶过表达,高表达的Aurora激酶导致异常的有丝分裂,引起基因的不稳定性,与肿瘤的发生、增殖、预后密切相关,表明其是一种新型抗肿瘤靶点。目前Aurora激酶抑制剂是分子靶向治疗的新领域,部分抑制剂已进入临床试验,表现出较强的抗肿瘤活性。本文就Aurora激酶生物学特性及其抑制剂与消化道肿瘤发生发展的关系进行综述。Abstract: Aurora kinases constitute a highly evolutionarily conserved family of serine/threonine kinases, which includes Aurora A, Aurora B, and Aurora C. These kinases are dynamically distributed throughout the cell cycle, and ensure the normal completion of the cell cycle by regulating centrosome maturation and separation, bipolar spindle assembly and stabilization, accurate separation of chromosomes, and efficient division of cytoplasm during mitosis. In recent years, it has been shown that Aurora kinases are overexpressed in a variety of solid tumors in the human body. The overexpression of Aurora kinases leads to abnormal mitosis, causes genetic instability, and is closely related to the occurrence, proliferation, and poor prognosis of tumors, which indicates that these kinases could be novel anti- tumor targets. Currently, Aurora kinase inhibitors are considered as novel candidates for molecular targeted therapies. Some of these inhibitors with strong anti-tumor activity have even entered clinical trials. In this article, we have reviewed the relationship between the biological characteristics of Aurora kinases, Aurora kinase inhibitors, and the occurrence and development of gastrointestinal tumors.
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Key words:
- Aurora kinases /
- mitosis /
- gastrointestinal tumors
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