2019年度国家自然科学基金临床肿瘤研究方向分析及思考

Analysis and reflection on the research directions of clinical oncology projects of National Natural Science Foundation of China in 2019

摘要: 随着细胞生物学等学科的不断发展和深入，肿瘤学基础研究取得了一定进展，肿瘤学科申请项目数量及质量也逐渐提高。本文总结2019年度国家自然科学基金临床肿瘤学科面上项目、青年科学基金项目以及地区科学基金项目的申请与资助情况，并从不同角度深入分析面上项目的研究方向，针对临床肿瘤中非编码RNA、肿瘤免疫治疗、肿瘤微环境、肿瘤代谢等代表性研究方向，以及淋巴管新生、细胞焦亡及铁死亡、溶酶体及线粒体等研究前沿进行综述。

Abstract: Owing to the developments in cell biology and other related disciplines, basic oncological research has progressed. There has been a gradual increase in the quantity and quality of research applications for oncology. This paper provided an overview of the applications and fundings (General Program, Youth Program and Regional Program) for clinical oncology of the National Natural Science Foundation of China in 2019, analyzed the research directions of the General Program from different perspectives and discussed representative research directions including non- coding RNA, immunotherapy, microenvironment, metabolism, as well as frontiers such as lymphangiogenesis, pyroptosis and ferroptosis, lysosome and mitochondrion in the field of clinical oncology.