近红外荧光成像技术在外科手术中的研究进展

刘丹丹; 罗林; 崔永言

doi:10.3969/j.issn.1000-8179.2020.06.194

近红外荧光成像技术在外科手术中的研究进展

doi: 10.3969/j.issn.1000-8179.2020.06.194

北京大学深圳医院整形外科(广东省深圳市 518036)

详细信息

作者简介:
刘丹丹专业方向为近红外荧光实时引导皮肤肿瘤切除等。E-mail:liudandan4674@163.com

通讯作者:
崔永言 cyy8188@163.com

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出版历程
- 收稿日期: 2020-03-03
- 刊出日期: 2020-12-26

Research progress of near-infrared fluorescence imaging technology in surgery

Department of Plastic Surgery, Shenzhen Hospital of Beijing University, Shenzhen 518036, China

More Information

Corresponding author: Yongyan Cui; E-mail: cyy8188@163.com

摘要

摘要: 作为术中导航的新兴领域，近红外荧光（near-infrared fluorescence，NIRF）成像技术能借助荧光探针对特定的生物组织进行显像，从而在外科手术中实时获取血管、淋巴管和特定组织的视觉信息，从而发现传统方法无法识别的微小灶，正确显示肿瘤切缘，帮助外科医生进行术中决策。该技术由于其操作简单，快速实时，安全无害，具有良好的应用前景。本文将就NIRF成像技术的基本原理，在实时引导肿瘤切除，前哨淋巴结定位，保护正常解剖结构等方面的临床进展进行综述，并且讨论了该技术的局限性和优势并展望其应用前景。
- 近红外荧光 /
- 术中导航 /
- 吲哚菁绿
Abstract: Near-infrared fluorescence (NIRF) imaging is an emerging technology that aids in real-time intraoperative navigation. NIRF uses fluorescent dyes and probes to obtain real-time anatomical and functional information of blood and lymphatic vasculature and specific tissues during surgery. It can identify small cancerous growths and tumor margins that cannot be normally detected by traditional methods, thus providing the surgeons with a perioperative, anatomical guidance and identification modality to make correct intraoperative decisions. NIRF is promising owing to the following aspects:real-time, sensitive, safe, non-invasive, relatively cheap, and non-ionizing; it has the potential to bring a revolution in the existing surgical techniques. This article comprehensively reviews the basic principles of NIRF imaging technology, the clinical progress in real-time guided tumor resection, sentinel lymph node mapping for cancer staging, and protection of critical anatomical structures during surgery. Furthermore, this review discusses the advantages and limitations of NIRF technology and potential future prospects for its application.
- near-infrared fluorescence /
- intraoperative navigation /
- indocyanine green

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参考文献(36)

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