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摘要: 铁死亡是近年来新发现的一种程序性细胞死亡形式，其特征是脂质活性氧的铁依赖性堆积，并在乳腺癌等疾病中起着重要的作用。乳腺癌是女性常见的恶性肿瘤之一，虽其病因及发病机制尚未阐明，但通过激活铁死亡途径能抑制乳腺癌细胞增殖，改善对化疗药物的耐药性，增强对放疗的敏感性及抑制癌细胞远处转移，可作为乳腺癌患者治疗的潜在新靶点。本文将对铁死亡发生机制及在乳腺癌治疗中的作用进行综述。Abstract: Ferroptosis, a recently discovered form of programmed cell death characterized by iron-dependent accumulation of lipid reactive oxygen species, plays an important role in diseases such as breast cancer. Although breast cancer is a common malignant tumor in women, its etiology and pathogenesis remain unclear. However, activation of the ferroptosis pathway is known to affect breast cancer cells by inhibiting their proliferation, mitigating their resistance to chemotherapy drugs, enhancing their sensitivity to radiotherapy, and inhibiting their distant metastases; thus, the ferroptosis pathway is a potential novel target for the treatment of breast cancer. Herein, we summarize the mechanisms of ferroptosis and its potential role in breast cancer treatment.
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Key words:
- ferroptosis /
- breast cancer /
- treatment /
- reactive oxygen species
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表 1 铁死亡相关诱导剂和抑制剂
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