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摘要: 肺结核和肺癌均严重危害着人类健康,每年分别造成上百万患者死亡。特别在发展中国家,两种疾病均存在较高的发病率。已有流行病学研究证据表明,结核病增加了肺癌的患病风险。肺结核和肺癌预后不同,但在病因方面关系密切。肺结核可以通过慢性炎症刺激、免疫异常、瘢痕及钙化灶、基因突变及药物影响等因素增加肺癌的发生几率。本文就肺结核在肺癌发病机制方面的研究进行综述,为肺结核患者提前进行干预并降低肺癌发生提供参考。Abstract: Tuberculosis and lung cancer are two important health hazards that cause millions of deaths every year. Both diseases have high incidence rates, particularly in developing countries. Epidemiological evidence has shown that pre-existing tuberculosis increases the risk of concomitant lung cancer. Although the prognoses of the two diseases may be different, they share a common etiology. Many studies have confirmed that pre-existing tuberculosis can enhance the development of lung cancer by stimulating chronic inflammation, immune abnormalities, scarring and calcifications, gene mutations and drug effects. This review comprehensively discusses the research status and molecular mechanisms related to tuberculosis with respect to lung cancer pathogenesis to provide precautionary measures for tuberculosis patients at risk of lung cancer
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Key words:
- tuberculosis /
- lung cancer /
- pathogenesis /
- Mycobacterium tuberculosis /
- inflammation
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