Abstract: Breast conservation surgery and oncoplastic breast surgery have been increasingly used for surgically managing breast cancer worldwide. For most patients with ipsilateral local recurrence after breast conservation therapy, salvage mastectomy is required, rendering them to a state of loss of breast mounds. Because most patients have a history of prior chest wall radiation and systemic therapy, breast reconstruction has unique characteristics and requires special considerations in these patients. A literature review was performed to summarize oncological safety, short-and long-term postoperative complications, and postoperative esthetic results for patients who undergo salvage mastectomy and immediate breast reconstruction to provide evidence to better assist surgeons in surgical planning and management of patients.