癌性厌食发病机制和临床诊疗的研究进展

Progress on pathogenesis, clinical diagnosis and treatment of cancer-related anorexia

摘要: 癌性厌食（cancer-related anorexia，CA）可贯穿癌症患者疾病全程且易被忽略，发病率为40%~80%。CA会导致患者摄食量减少、营养不良、体质量下降，最终导致癌症厌食恶病质综合征（cancer anorexia cachexia syndrome，CACS）。CA的发病机制复杂，评估标准尚存争议，缺乏可靠有效的治疗药物。因此，CA发病机制的阐述，规范化食欲评估标准的制定及相关药物的研发，对于癌症治疗疗效、提高患者生存质量极为重要。本文旨在阐述CA的发病机制、临床常用评估方法及治疗进展。

Abstract: Cancer-related anorexia (CA) presents in 40%-80% of cancer patients and is often ignored. CA can lead to decreased food intake, malnutrition, weight loss, and even cancer anorexia-cachexia syndrome (CACS). The pathogenesis of CA is complex, and the available diagnostic criteria are controversial. In addition, there is a lack of effective treatments. Thus, elucidating the pathogenesis of CA is imperative for improving the therapeutic effects of cancer treatment and patients' quality of life. For this purpose, a set of accurate appetite assessment tools and efficient drugs are needed. Herein, we aimed to review the pathogenesis and clinical diagnostic methods for CA as well as the progress made in its treatment.