Abstract: Breast cancer is the most common malignant cancer in women, and it seriously threatens women's health. However, the mechanisms underlying its pathogenesis remain elusive, and clinical treatment remains difficult despite some remarkable results. Caveolea is a type of plasma membrane invagination existing on the cell surface that is covered by Caveolin, which plays a series of important functions such as transport and signal transduction. As a pivotal component of Caveolea, Caveolin1 is involved in regulating physiological activities such as endocytosis, signal transduction, lipid transport, and cell invasion. This review mainly focuses on the role of Caveolin1 in breast cancer and its epigenetic regulation mechanisms.