Research progress on thyroglobulin and anti-thyroglobulin antibodies in the diagnosis and treatment of differentiated thyroid cancer
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摘要: 分化型甲状腺癌(differentiated thyroid cancer,DTC)作为目前发病率上升最快、甲状腺外科最常见的内分泌恶性肿瘤而备受关注。通常选择甲状腺全切或近全切除术,术后配合甲状腺激素替代治疗以及131I消融治疗。甲状腺球蛋白(thyroglobulin,Tg)作为DTC术后随访的血清学标志物,易受到甲状腺球蛋白抗体(thyroglobulin antibody,TgAb)的干扰。本文着重探讨Tg、TgAb在DTC诊治中的意义,以期为研究提供更多的临床依据。Abstract: Differentiated thyroid cancer (DTC) is a malignant endocrine tumor with a rapidly increasing incidence. It is the most common cancer in thyroid surgery and has attracted much attention. Total or near-total thyroidectomy is usually performed, followed by thyroid hormone replacement therapy and 131I ablation. Thyroglobulin (Tg), a serological marker used in the postoperative follow-up of DTC, is susceptible to interference by thyroglobulin antibody (TgAb). In this review, we will focus on the significance of Tg and TgAb in the diagnosis and treatment of DTC to provide evidence for future clinical studies.
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