胃癌不同部位特征和预后的对比分析及临床意义

韩涛; 夏文彬; 吕扬; 梁寒; 王东浩

doi:10.3969/j.issn.1000-8179.2020.23.367

胃癌不同部位特征和预后的对比分析及临床意义

Comparative analysis of the features and prognoses of gastric cancer at different sites

摘要

摘要:
目的探讨胃癌不同部位的临床特点差异及预后的不同。
方法分析2010年1月至2014年12月于天津医科大学肿瘤医院行胃癌根治术的患者，按照肿瘤部位分为胃上部癌组、胃中部癌组、胃下部癌组、多部位癌组，对比各组患者性别构成比、年龄、Borrmann分型、肿瘤最大径、病理类型、TNM分期、临床分期、软组织转移情况等临床特点及预后。
结果 481例患者总体1、3、5年生存率分别为77.1%、46.0%和31.0%。各组患者生存率差异均具有统计学意义（均P < 0.05）。临床特点方面，各组患者在性别构成比（P < 0.001）、Borrmann分型（P < 0.001）、病理类型（P=0.001）、肿瘤最大径（P < 0.001）、T分期（P < 0.001）、N分期（P < 0.001）、临床分期（P < 0.001）、淋巴结外软组织转移（P < 0.001）方面差异均具有统计学意义；在年龄（P=0.260）、M分期（P=0.189）方面差异无统计学意义。
结论不同部位胃癌的临床特点和预后均具有显著性差异，临床中需根据患者情况开展个体化治疗。

Abstract:
Objective To investigate the clinical characteristics and prognoses of gastric cancer at different sites.
Methods Patients who underwent radical gastrectomy at Tianjin Medical University Cancer Institute and Hospital from January 2010 to December 2014 were selected and divided into four tumor location-based groups: upper gastric cancer, middle gastric cancer, lower gastric cancer, and multiple site gastric cancer. Clinical characteristics and prognosis were compared among the groups.
Result The overall 1-year, 3-year, and 5-year survival rates were 77.1%, 46.0%, and 31.0%, respectively. Survival rates differed significantly among the four groups. In terms of clinical characteristics, there were significant differences in the sex ratio, Borrmann classification, pathological type, maximum tumor diameter, T stage, N stage, clinical stage, and presence of soft tissue metastasis among the groups.
Conclusions The clinical characteristics and prognoses of gastric cancer were significantly different according to different sites of gastric cancer. Therefore, individualized treatment should be carried out according to the patient's condition.

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