Abstract:
As a novel regulatory model of cell death, ferroptosis is characterized by the excessive iron-dependent accumulation of lipid reactive oxygen species. Ferroptosis is related to a variety of biological pathways, including those involved in the metabolism of amino acids, lipids, and iron. At present, ferroptosis is known to be closely related to the occurrence, development, and treatment of cancer and to play a dual role in tumor immunity. Ferroptosis promotes tumor cell death to facilitate anti-tumor immunity; on the other side, it helps neighboring tumor cells escape immune-mediated killing and promotes tumor growth. This article discusses the latest research on ferroptosis, which is expected to produce novel ideas for tumor immunotherapy