李幸, 魏雪晴, 王丽, 张坦, 潘毅, 陈颖, 忻晓洁. LncRNA PVT1及PD-L1表达与顺铂耐药上皮性卵巢癌临床病理特征及预后的相关性分析[J]. 中国肿瘤临床, 2021, 48(2): 60-65. DOI: 10.3969/j.issn.1000-8179.2021.02.784
引用本文: 李幸, 魏雪晴, 王丽, 张坦, 潘毅, 陈颖, 忻晓洁. LncRNA PVT1及PD-L1表达与顺铂耐药上皮性卵巢癌临床病理特征及预后的相关性分析[J]. 中国肿瘤临床, 2021, 48(2): 60-65. DOI: 10.3969/j.issn.1000-8179.2021.02.784
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Xing Li, Xueqing Wei, Li Wang, Tan Zhang, Yi Pan, Ying Chen, Xiaojie Xin. The clinical and prognostic significance of lncRNA PVT1 and PD-L1 expression in cisplatin resistant epithelial ovarian cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(2): 60-65. DOI: 10.3969/j.issn.1000-8179.2021.02.784
Citation: Xing Li, Xueqing Wei, Li Wang, Tan Zhang, Yi Pan, Ying Chen, Xiaojie Xin. The clinical and prognostic significance of lncRNA PVT1 and PD-L1 expression in cisplatin resistant epithelial ovarian cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(2): 60-65. DOI: 10.3969/j.issn.1000-8179.2021.02.784
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LncRNA PVT1及PD-L1表达与顺铂耐药上皮性卵巢癌临床病理特征及预后的相关性分析

The clinical and prognostic significance of lncRNA PVT1 and PD-L1 expression in cisplatin resistant epithelial ovarian cancer

    摘要
  • 摘要:
      目的  探讨顺铂耐药性上皮性卵巢癌（cisplatin resistant epithelial ovarian cancer，CREOC）患者的长链非编码核糖核酸（long non-coding ribose nucleic acid，LncRNA）的浆细胞瘤异位基因1（plasma cytoma variant translocation1，PVT1）和程序性死亡配体1（programmed cell death-ligand 1，PD-L1）的表达关系及其作用。
      方法  收集2014年1月至2017年12月139例于天津医科大学肿瘤医院经病理诊断为上皮性卵巢癌患者的临床病理资料，采用实时荧光定量PCR（real-time fluorescent quantitative PCR，RT-qPCR）和免疫组织化学法分别检测CREOC组织中的LncRNA PVT1和PD-L1表达，分析其与临床病理特征及预后的相关性。
      结果  CREOC组织中的LncRNA PVT1和PD-L1表达均显著高于正常卵巢组织（P < 0.05）。CREOC组织中的LncRNA PVT1和PD-L1表达呈正相关（r=0.629，P < 0.001）。LncRNA PVT1和PD-L1的高表达与组织学分级、FIGO分期和淋巴结转移有关（P < 0.05）。Ln? cRNA PVT1高表达与残留病灶大小、血清CA125水平有关（P < 0.05）。单因素Logistic生存分析显示，LncRNA PVT1和PD-L1的高表达患者的无进展生存期（progression-free survival，PFS）和总生存期（overall survival，OS）明显低于LncRNA PVT1和PD-L1的低表达者（P < 0.05）。
      结论  CREOC患者组织中LncRNA PVT1和PD-L1的表达明显增高，且LncRNA PVT1的表达与PD-L1呈正相关。LncRNA PVT1和PD-L1的高表达与CREOC患者临床病理特征中的更具侵袭性及较差的预后相关。

     

    Abstract:
      Objective  To investigate the relationship between long non-coding ribonucleic acid (lncRNA) and programmed cell death-ligand 1 (PD-L1) expression in cisplatin resistant epithelial ovarian cancer (CREOC).
      Methods  The clinical data was collected from 139 patients diagnosed with epithelial ovarian cancer by pathology in Tianjin Medical University Cancer Institute and Hospital between January 2014 and December 2017. The lncRNA plasma cytoma variant translocation 1 (PVT1) and PD-L1 were detected by real-time fluorescent quantitative PCR (RT-qPCR) and immunohistochemistry of ovarian cancer tissues to explore their clinical and prognostic significance.
      Results  The expressions of LncRNA PVT1 and PD-L1 in CREOC tissues were significantly higher than those in normal ovarian tissues (P < 0.05). LncRNA PVT1 and PD-L1 levels in CREOC tissues was positively correlated (r=0.629, P < 0.001). The high expression of LncRNA PVT1 and PD-L1 was correlated with histological grade, FIGO stage and lymph node metastasis (P < 0.05). High expression of LncRNA PVT1 was correlated with residual lesion size and serum CA125 level (P < 0.05). In the Logistic survival analysis, CREOC patients with high PVT1 and PD-L1 expression displayed shorter progression- free survival (PFS) and overall survival (OS) than patients with low PVT1 and PD-L1 expression.
      Conclusions  The expression of LncRNA PVT1 and PD-L1 in CREOC patients was significantly higher than in controls. The expression of LncRNA PVT1 was positively correlated with PD-L1 expression. Over expression of LncRNA PVT1 and PD-L1 is associated with more aggressive clinicopathological characteristics and poor prognosis in CREOC patients.

     

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