Abstract:
Objective To explore the difference in D-dimer levels in patients with single gastric cancer (GC) and GC combined with type 2 diabetes mellitus (T2DM). In addition, the association of plasma D-dimer level with clinicopathological characteristics and prognosis in patients with T2DM were investigated.
Methods The clinical and follow-up data of 996 patients diagnosed with GC at The First Affiliated Hospital of Zhengzhou University between September 2010 and October 2018 were retrospectively analyzed using relevant statistical methods. The patients were grouped according to whether they were complicated with T2DM or not, and included 190 cases in the combined group and 806 cases in the single group. The Kaplan-Meier method and Cox regression were used for survival analyses.
Results Compared with the single group, the combined group had significantly higher D-dimer levels (P < 0.05). In the combined group, D-dimer levels were significantly associated with TNM stage, distant metastasis, and tumor size (P < 0.05). Multivariate analysis further revealed that D-dimer levels remained an independent prognostic risk factor for the survival of patients with GC with T2DM (P < 0.05), and the difference in overall survival between patients in the D-dimer level sub-groups was statistically significant with a HR of 1.958 (95% CI: 1.028-3.728).
Conclusions Patients with GC combined with T2DM are hypercoagulable. D-dimer levels can be useful for the clinical monitoring and prognosis of patients with GC combined with T2DM.
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