癌症相关性孤立下肢远端深静脉血栓形成的临床研究进展

祝杰; 龙波; 刘海霞

doi:10.3969/j.issn.1000-8179.2021.04.263

癌症相关性孤立下肢远端深静脉血栓形成的临床研究进展

doi: 10.3969/j.issn.1000-8179.2021.04.263

重庆大学附属肿瘤医院心血管呼吸内科（重庆市404000）

基金项目:

重庆市卫生适宜技术推广项目 2019jstg047

详细信息

作者简介:
祝杰专业方向为肿瘤心脏病学。E-mail：462440842@qq.com

通讯作者:
刘海霞 haixial222@163.com

计量
- 文章访问数: 254
- HTML全文浏览量: 26
- PDF下载量: 31
- 被引次数: 0
出版历程
- 收稿日期: 2020-09-27
- 刊出日期: 2021-02-28

Clinical research progress on the management of patients with cancer related isolated distal deep vein thrombosis

Department of Cardiovascular and Respiratory, Chongqing University Cancer Hospital, Chongqing 404000, China

Funds:

Chongqing Municipal Health Appropriate Technology Promotion Project 2019jstg047

More Information

Corresponding author: Haixia Liu; E-mail: haixial222@163.com

摘要

摘要: 静脉血栓栓塞症（venous thromboembolism，VTE）在癌症患者中发病率较高，是导致癌症患者疾病进展或死亡的重要因素。下肢深静脉血栓（deep vein thrombosis，DVT）形成在VTE中占比多、危害大，可分为近端DVT形成（proximal deep vein thrombosis，PDVT）及孤立性下肢远端DVT形成（isolated distal deep vein thrombosis，IDDVT）。PDVT的风险评估及管理策略已有较多研究，然而对约占下肢DVT 50%的IDDVT却鲜有研究，临床工作中对癌症相关性IDDVT的风险评估及管理策略也欠规范，因此本文对癌症相关性孤立下肢远端深静脉血栓形成的临床研究进行综述。
- 孤立性下肢远端深静脉形成 /
- 静脉血栓栓塞症 /
- 恶性肿瘤 /
- 癌症
Abstract: Patients with malignant tumors have a high incidence of venous thromboembolism (VTE). In addition, VTE is an important factor in the progression of cancer and the death of patients with cancer. Deep vein thrombosis (DVT), which comprises proximal deep vein thrombosis (PDVT) and isolated distal deep vein thrombosis (IDDVT), of the lower extremities accounts for a large proportion of VTEs and causes great harm. The risk of and management strategies for PDVT have been well studied. However, we know little about IDDVT, which accounts for about half the cases of DVT of the lower extremities. The clinical risk of and therapies for cancer-related IDDVT are still being studied. We summarize the current status of clinical studies on the management of patients with IDDVT, especially those with a history of cancer.
- isolated distal deep vein thrombosis (IDDVT) /
- venous thromboembolism (VTE) /
- malignant tumor /
- cancer

HTML全文

参考文献(32)

[1]	中国临床肿瘤学会肿瘤与血栓专家委员会. 肿瘤相关静脉血栓栓塞症预防与治疗指南(2019版)[J]. 中国肿瘤临床, 2019, 46(13): 653-660. doi: 10.3969/j.issn.1000-8179.2019.13.765
[2]	De MG, Bochanen N, van Rooijen G, et al. Analysis of 1 338 patients with acute lower limb deep venous thrombosis (DVT) supports the inadequacy of the term "proximal DVT"[J]. Eur J Vasc Endovasc Surg, 2016, 51(3): 415-420. doi: 10.1016/j.ejvs.2015.11.001
[3]	Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report[J]. Chest, 2016, 150(4): 988. http://www.bmj.com/lookup/external-ref?access_num=10.1016/j.chest.2015.11.026&link_type=DOI
[4]	Palareti G, Schellong S. Isolated distal deep vein thrombosis: what we know and what we are doing[J]. J Thromb Haemost, 2012, 10(1): 11- 19. doi: 10.1111/j.1538-7836.2011.04564.x
[5]	Galanaud JP, Sevestre-Pietri MA, Bosson JL, et al. Comparative study on risk factors and early outcome of symptomatic distal versus proximal deep vein thrombosis: results from the OPTIMEV study[J]. Thromb Haemost, 2009, 102(3): 493-500. http://www.ncbi.nlm.nih.gov/pubmed/19718469
[6]	Poudel SK, Park DY, Jia X, et al. Clinical outcomes of isolated distal deep vein thrombosis versus proximal venous thromboembolism in cancer patients: The cleveland clinic experience[J]. J Thromb Haemost, 2020, 18(3): 651-659. doi: 10.1111/jth.14700
[7]	Labropoulos N, Waggoner T, Sammis W, et al. The effect of venous thrombus location and extent on the development of post-thrombotic signs and symptoms[J]. J Vasc Surg, 2008, 48(2): 407-412. doi: 10.1016/j.jvs.2008.03.016
[8]	Seinturier C, Bosson JL, Colonna M, et al. Site and clinical outcome of deep vein thrombosis of the lower limbs: an epidemiological study[J]. J Thromb Haemost, 2005, 3(7): 1362-1367. doi: 10.1111/j.1538-7836.2005.01393.x
[9]	Tick LW, Kramer MH, Rosendaal FR, et al. Risk factors for postthrombotic syndrome in patients with a first deep venous thrombosis[J]. J Thromb Haemost, 2008, 6(12): 2075-2081. doi: 10.1111/j.1538-7836.2008.03180.x
[10]	Palareti G, Cosmi B, Lessiani G, et al. Evolution of untreated calf deep- vein thrombosis in high risk symptomatic outpatients: the blind, prospective CALTHRO study[J]. Thromb Haemost, 2010, 104 (5): 1063-1070.
[11]	Schwarz T, Buschmann L, Beyer J, et al. Therapy of isolated calf muscle vein thrombosis: a randomized, controlled study[J]. J Vasc Surg, 2010, 52(5): 1246-1250. doi: 10.1016/j.jvs.2010.05.094
[12]	Sales CM, Haq F, Bustami R, et al. Management of isolated soleal and gastrocnemius vein thrombosis[J]. J Vasc Surg, 2010, 52(5): 1251-1254. doi: 10.1016/j.jvs.2010.05.102
[13]	Righini M, Paris S, Le Gal G, et al. Clinical relevance of distal deep vein thrombosis. Review of literature data[J]. Thromb Haemost, 2006, 95(1): 56-64. doi: 10.1160/TH05-08-0588
[14]	De Martino RR, Wallaert JB, Rossi AP, et al. A meta-analysis of anticoagulation for calf deep venous thrombosis[J]. J Vasc Surg, 2012, 56(1): 228-237. doi: 10.1016/j.jvs.2011.09.087
[15]	Stein PD, Matta F, Musani MH, et al. Silent pulmonary embolism in patients with deep venous thrombosis: a systematic review[J]. Am J Med, 2010, 123(5): 426-431. doi: 10.1016/j.amjmed.2009.09.037
[16]	Horner D, Hogg K, Body R, et al. The anticoagulation of calf thrombosis (ACT) project: results from the randomized controlled external pilot trial[J]. Chest, 2014, 146(6): 1468-1477. doi: 10.1378/chest.14-0235
[17]	Galanaud JP, Sevestre MA, Pernod G, et al. Long-term outcomes of cancer-related isolated distal deep vein thrombosis: the OPTIMEV study[J]. J Thromb Haemost, 2017, 15(5): 907-916. doi: 10.1111/jth.13664
[18]	Dentali F, Pegoraro S, Barco S, et al. Clinical course of isolated distal deep vein thrombosis in patients with active cancer: a multicenter cohort study[J]. J Thromb Haemost, 2017, 15(9): 1757-1763. doi: 10.1111/jth.13761
[19]	Franco L, Giustozzi M, Agnelli G, et al. Anticoagulation in patients with isolated distal deep vein thrombosis: a meta- analysis[J]. J Thromb Haemost, 2017, 15(6): 1142-1154. doi: 10.1111/jth.13677
[20]	McLafferty RB, Moneta GL, Passman MA, et al. Late clinical and hemodynamic sequelae of isolated calf vein thrombosis[J]. J Vasc Surg, 1998, 27(1): 50-57. doi: 10.1016/S0741-5214(98)70291-5
[21]	Saarinen JP, Domonyi K, Zeitlin R, et al. Postthrombotic syndrome after isolated calf deep venous thrombosis: the role of popliteal reflux[J]. J Vasc Surg, 2002, 36(5): 959-964. doi: 10.1067/mva.2002.127523
[22]	Wille-Jørgensen P, Jorgensen LN, Crawford M. Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome. A systematic review and meta- analysis[J]. Thromb Haemost, 2005, 93(2): 236-241. doi: 10.1160/TH04-09-0570
[23]	Schulman S, Granqvist S, Juhlin-Dannfelt A, et al. Long-term sequelae of calf vein thrombosis treated with heparin or low-dose streptokinase[J]. Acta Med Scand, 1986, 219(4): 349-357. http://europepmc.org/abstract/MED/3521207
[24]	Dentali F, Barco S, Pegoraro S, et al. Residual vein obstruction in patients diagnosed with acute isolated distal deep vein thrombosis associated with active cancer[J]. J Thromb Thrombolysis, 2018, 46 (3): 404-408. doi: 10.1007/s11239-018-1708-0
[25]	Lagerstedt CI, Olsson CG, Fagher BO, et al. Need for long-term anticoagulant treatment in symptomatic calf- vein thrombosis[J]. Lancet, 1985, 2(8454): 515-518. http://www.ncbi.nlm.nih.gov/pubmed/2863541
[26]	Lautz TB, Abbas F, Walsh SJ, et al. Isolated gastrocnemius and soleal vein thrombosis: should these patients receive therapeutic anticoagulation[J]? Ann Surg, 2010, 251(4): 735-742. doi: 10.1097/SLA.0b013e3181c1ae95
[27]	Utter GH, Dhillon TS, Salcedo ES, et al. Therapeutic anticoagulation for isolated calf deep vein thrombosis[J]. JAMA Surg, 2016, 151(9): e161770. doi: 10.1001/jamasurg.2016.1770
[28]	Yoon DY, Riaz A, Teter K, et al. Surveillance, anticoagulation, or filter in calf vein thrombosis[J]. J Vasc Surg Venous Lymphat Disord, 2017, 5(1): 25-32. doi: 10.1016/j.jvsv.2016.08.007
[29]	Ageno W, Mantovani L, Haas S, et al. Patient management strategies and long-term outcomes in isolated distal deep-vein thrombosis versus proximal deep- vein thrombosis: Findings from XALIA[J]. TH Open, 2019, 3(01): e85-e93. doi: 10.1055/s-0039-1683968
[30]	Righini M, Galanaud JP, Guenneguez H, et al. Anticoagulant therapy for symptomatic calf deep vein thrombosis (CACTUS): a randomised, double-blind, placebo-controlled trial[J]. Lancet Haematol, 2016, 3(12): e556-e562. doi: 10.1016/S2352-3026(16)30131-4
[31]	Brahmandam AS, Brownson K, Skrip L, et al. Management of isolated calf vein thrombosis in cancer patients[J]. Vascular, 2016, 24(1): 64-69. doi: 10.1177/1708538115584726
[32]	Nicolaides AN, Fareed J, Kakkar AK, et al. Prevention and treatment of venous thromboembolism- international consensus statement [J]. Int Angiol, 2013, 32(2): 111-260.