Abstract:
Objective To analyze the effect of individualized diagnosis and treatment of chemotherapy-induced nausea and vomiting (CINV) in the real world on the control rate of CINV and quality of life in patients with gastrointestinal cancer.
Methods From October 2018 to October 2020, 289 patients with gastrointestinal cancer who were admitted to the Fourth Hospital of Hebei Medical University and received a chemotherapy regimen with moderate CINV risk were recruited.Patients were assigned into an individualized CINV treatment group (group A) and a doctor evaluation treatment group (group B).The control rate of CINV and its influence on quality of life were compared between the two groups.
Results There were 146 and 143 cases in groups A and B, respectively.The complete control rates of nausea(74.66% vs.34.27%, P < 0.001)and vomiting(87.67% vs.55.94%, P < 0.001)were significantly better in group A than in group B.The complete control rates of nausea and vomiting during the acute and delayed phases in group A were significantly better than those in group B.Meanwhile, patients in group A showed significant advantages in terms of quality of life, with respect to functional domains(physical function, role function, and social function), symptom domains(nausea and vomiting, fatigue, insomnia, and anorexia), and overall health status.
Conclusions Individualized CINV treatment can significantly improve the CINV control rate and quality of life in patients with gastrointestinal cancer.