Abstract: Immunotherapy has been proved to be one of the most promising treatments for advanced malignant solid tumors. It was found that the immune activation and immune effect caused by tumors mainly came from the interaction between tumor antigens and tumor microenvironment (TME), and the weakened immunogenicity of tumor antigens and the deficiency of immune response pathway were the main causes for immune escaping. Immunotherapy is able to enhance the ability of antigen presentation, activate the immune response and improve the immunosuppressive status of TME via different ways, and then, improving the survival benefits. Whereas, the effect of immunotherapy is positively correlated with the drug concentration-a higher therapeutic dose is often effective, which will cause different degree of immune-related toxicities and even induce drug resistance in vivo. Therefore, a new treatment method, local immunotherapy, aiming to elevate local drug concentrationhas but with a good tolerance, has been explored and gotten an early clinical efficacy. This article will describe the activated mechanisms, application characteristics and clinical development of several immune drugs using in locally.