弭丽丽, 殷飞, 雷连会, 段晓玲, 李宁, 殷小磊, 史建飞, 韩欣, 赵曼, 王金凤, 韩光洁, 赵新明. 18F-FDG PET/CT相关参数与胃癌患者HER2表达状态的相关性研究[J]. 中国肿瘤临床, 2021, 48(6): 301-305. DOI: 10.3969/j.issn.1000-8179.2021.06.261
引用本文: 弭丽丽, 殷飞, 雷连会, 段晓玲, 李宁, 殷小磊, 史建飞, 韩欣, 赵曼, 王金凤, 韩光洁, 赵新明. 18F-FDG PET/CT相关参数与胃癌患者HER2表达状态的相关性研究[J]. 中国肿瘤临床, 2021, 48(6): 301-305. DOI: 10.3969/j.issn.1000-8179.2021.06.261
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Lili MI, Fei YIN, Lianhui LEI, Xiaoling DUAN, Ning LI, Xiaolei YIN, Jianfei SHI, Xin HAN, Man ZHAO, Jinfeng WANG, Guangjie HAN, Xinming ZHAO. Correlation of HER2 expression with 18F-FDG PET/CT parameters in patients with gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(6): 301-305. DOI: 10.3969/j.issn.1000-8179.2021.06.261
Citation: Lili MI, Fei YIN, Lianhui LEI, Xiaoling DUAN, Ning LI, Xiaolei YIN, Jianfei SHI, Xin HAN, Man ZHAO, Jinfeng WANG, Guangjie HAN, Xinming ZHAO. Correlation of HER2 expression with 18F-FDG PET/CT parameters in patients with gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(6): 301-305. DOI: 10.3969/j.issn.1000-8179.2021.06.261
shu

18F-FDG PET/CT相关参数与胃癌患者HER2表达状态的相关性研究

Correlation of HER2 expression with 18F-FDG PET/CT parameters in patients with gastric cancer

    摘要
  • 摘要:
      目的  探讨18F-FDG PET/CT相关参数对预测胃癌患者HER2表达状态的价值。
      方法  回顾性分析2000年1月至2020年3月河北医科大学第四医院115例经手术病理证实的胃癌患者临床资料，且术前均行PET/CT检查，分析胃癌原发病灶的最大标准化摄取值（maximum standard uptake value，SUVmax）、肿瘤代谢体积（metabolic tumor volume，MTV）和总糖酵解量（tumor lesion gly-colysis，TLG）以及HER2的表达状态，采用单因素和多元Logistic回归分析的方法，评价PET/CT各参数与HER2表达的相关性。
      结果  HER2表达阳性17例，阴性98例。SUVmax、MTV及TLG在HER2表达阳性与阴性者之间无显著性差异（P>0.05）。但是在排除印戒细胞癌后（n=105），MTV和TLG在HER2阳性胃癌患者中明显低于HER2阴性者四分位数12.6（8.4，18.7）vs. 23.7（14.4，32.9），P=0.002；35.3（20.8，68.1）vs. 69.9（44.2，173.3），P < 0.001。MTV及TLG的最佳界值分别为24.3 cm3、35.9 g时，其预测HER2表达阳性的准确率分别为57.1%和80.9%。单因素分析显示肿瘤分化程度、病理分型、MTV及TLG与HER2表达相关，多元Logis-tic回归分析显示肠型（OR=6.804，P=0.009）、TLG≤35.9 g（OR=4.600，P=0.029）是预测HER2表达的指标。
      结论  TLG可以预测非印戒细胞胃癌患者HER2表达，用以指导治疗方案的选择。

     

    Abstract:
      Objective  To investigate the relationship between 2-deoxy-2-fluorine-18fluoro-D-glucose positron emission tomography/ computed tomography (18F-FDG PET/CT) parameters and HER2 expression in patients with gastric cancer.
      Methods  In total, 115 patients with gastric cancer from The Fourth Hospital of Hebei Medical University, confirmed by surgical pathology, were enrolled in this study. PET/ CT was performed before surgery. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and HER2 expression in primary tumors were measured. To evaluate the correlation between PET/CT measurements and HER2 expression by univariate and multivariate Logistic regression analyses, 17 HER2-positive and 98 HER2-negative patients were analyzed.
      Results  There were no statistical differences in SUVmax, MTV, and TLG between the HER2-positive and HER2-negative groups (P>0.05 for all comparisons). When signet-ring cell carcinoma patients were excluded from the analysis (n=105), the MTV and TLG were significantly lower in the HER2-positive group than in the HER2-negative group MTV: 12.6 (range 8.4, 18.7) vs. 23.7 (range 14.4, 32.9), P=0.002; TLG: 35.3 (range 20.8, 68.1) vs. 69.9 (range 44.2, 173.3), P < 0.001. The cut-off values for MTV and TLG were 24.3 cm3 and 35.9 g, respectively, and the accuracies of MTV and TLG for predicting HER2 expression were 57.1% and 80.9%, respectively. Univariate analysis showed that the degree of tumor differentiation, pathological classification, MTV, and TLG were correlated with HER2 expression. Intestinal type gastric cancer odds ratio (OR)=6.804, P=0.009 and TLG ≤35.9 g (OR=4.600, P=0.029) were predictive factors for HER2 expression in multivariate Logistic regression analysis.
      Conclusions  TLG of primary gastric tumors, except signet-ring cell carcinoma, could predict HER2 expression and be used to guide treatment decisions.

     

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