Abstract: Ferroptosis is a newly discovered form of programmed cell death that is characterized by lipid peroxidation damage to the iron-dependent membrane structure, which leads to the destruction of cell integrity and subsequently cell death. Ferroptosis is involved in many diseases, including cancer, ischemia-reperfusion injury, acute kidney injury, and nervous system. Recent studies have shown that ferroptosis plays an important role in the development and progression of tumors. In particular, it has potential significance in the research on the clinical transformation of digestive system tumors. This paper reviews the mechanism of ferroptosis in digestive system tumors and the progress in research on this topic.