生物蛋白胶载药缓释系统携载吉西他滨及顺铂治疗1例转移性胰腺癌

基金项目:

四川省卫健委课题基金 20PJ043

四川省科技厅课题基金 2021YJ0429

图 1 治疗前后患者CT和MRI

A：治疗前CT显示胰腺头部肿瘤（白色箭头）；B～C：术中CT引导下行经皮穿刺肿瘤内注射纤维蛋白胶+吉西他滨+顺铂混合液；D：治疗2天后MRI提示药物沉积良好，肿瘤完全坏死（箭头所示）；E～F：18个月后复查MRI提示肿瘤完全坏死；G：TACE术前的CT显示肝转移灶（白色箭头）；H：治疗后18个月复查CT提示碘化油在肝脏转移灶中沉积良好，无强化病灶

下载: 全尺寸图片幻灯片

图 2 胰腺腺癌的组织学特征

A：大面积的坏死区域和异质性肿瘤细胞（圆圈内；H&E×100）；B：肿瘤细胞散布在纤维组织中，呈线性或小巢状（圆圈内）；异形肿瘤细胞具有大且深染的细胞核和多形形状（六边形内；H&E×400）

下载: 全尺寸图片幻灯片

[1]	Louvet C, Labianca R, Hammel P, et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase Ⅲ trial[J]. J Clin Oncol, 2005, 23(15): 3509-16. doi: 10.1200/JCO.2005.06.023
[2]	Heinemann V, Quietzsch D, Gieseler F, et al. Randomized phase Ⅲ trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer[J]. J Clin Oncol, 2006, 24(24): 3946-3952. doi: 10.1200/JCO.2005.05.1490
[3]	Ogura Y, Mizumoto K, Tanaka M, et al. Strategy for prevention of local recurrence of pancreatic cancer after pancreatectomy: antitumor effect of gemcitabine mixed with fibrin glue in an orthotopic nude mouse model[J]. Surgery, 2006, 140(1): 66-71. doi: 10.1016/j.surg.2005.11.012
[4]	Yoshida H, Yamaoka Y, Shinoyama M, et al. Novel drug delivery system using autologous fibrin glue: Release properties of anti-cancer drugs[J]. Biol Pharm Bull, 2000, 23(3): 371-374.