Abstract:
Objective In China, intestinal-type gastric cancer accounts for 40%−45% of gastric cancers. This study aimed to evaluate the prognostic factors of patients with intestinal-type gastric cancer after radical resection.
Methods The clinicopathological and prognostic data of patients, who underwent radical resection and were pathologically diagnosed with primary intestinal-type gastric cancer between July 2010 and July 2015 in Shandong Provincial Hospital Affiliated to Shandong First Medical University, were retrospectively collected. Log-rank tests were used to compare the effects of clinicopathological features on disease-free survival (DFS) and overall survival (OS). Factors with P values < 0.10 in univariate analysis were included in multivariate Cox regression analysis.
Results In total, 374 patients were enrolled. The 5-year DFS rate was 73.4%, and the 5-year OS rate was 79.7%. Univariate analysis showed that age > 60 years, moderate histological differentiation, primary tumor diameter > 3 cm, T3−4 stage, lymph node invasion, advanced tumor-node-metastasis (TNM) stage, non-distal gastric cancer, lymphovascular invasion, neural invasion, human epidermal growth factor receptor-2 (HER-2) overexpression, and a high platelet-to-lymphocyte ratio (PLR) were poor prognostic factors (P < 0.05). Multivariate analysis indicated that age, neural invasion and TNM stage were independently associated with poor prognosis.
Conclusions Age > 60 years, moderate histological differentiation, primary tumor diameter > 3 cm, advanced TNM stage, non-distal gastric cancer, lymphovascular invasion, neural invasion, HER-2 overexpression, and a high PLR are the risk factors of poor prognosis in patients with intestinal-type gastric cancer after radical resection. Age, neural invasion and TNM stage are independent predictors of poor prognosis in patients with intestinal-type gastric cancer after radical resection.