Abstract: Breast cancer is a type of common malignant tumor for female in China, which seriously threatens the health and life of patients. Currently, the primary treatment for breast cancer includes chemotherapy, endocrine therapy, targeted therapies, and immunotherapy. Long non-coding RNAs (lncRNAs) regulate cell fates and play important roles in breast cancer. LncRNAs could be used as novel markers for clinical monitoring and molecular targeted therapies. In this article, we review the known functions of lncRNAs in breast cancer to provide new ideas for clinical surveillance and targeted therapies for breast cancer.