Objective  To investigate the safety and efficacy of endoscopic submucosal dissection (ESD) and endoscopic full-thickness resection (EFR) in the treatment of gastric submucosal tumors.

  Methods  The clinical data of 109 patients with gastric submucosal tumor were retrospectively analyzed. Sixty-two patients underwent ESD (ESD group) and 47 patients underwent EFR (EFR group). The baseline data, perioperative status, postoperative complications, duration of postoperative hospital stay, and postoperative pathological results of the two groups were summarized.

  Results  In the ESD group, 61 patients completed endoscopic surgery, and one underwent laparoscopic surgery. The average operation time was (65.08±30.36) min, and amount of intraoperative blood loss was (18.66±30.70) mL. Seven patients had a perforation; 24 wounds or perforationswere sutured with a purse string, 32 were sutured with a metal clip, and 5 were not sutured. In the EFR group, 46 patients completed endoscopic surgery, and one underwent laparoscopic surgery. The average operation time was (52.13±20.95) min, and the amount of bleeding was (17.06±23.25) mL. Twenty-five patients were sutured with a purse string, while 21 cases were sutured with a metal clip. There were two patients with delayed hemorrhage and two with delayed perforation in the ESD group, and there was one patient with delayed hemorrhage in the EFR group. In the ESD group, there were 36 cases of stromal tumor, 14 cases of leiomyoma, 5 cases of lipoma, 3 cases of ectopic pancreas, and 4 cases of others, while in the EFR group, there were 40 cases of stromal tumor, 3 cases of leiomyoma, and 4 cases of others. There was no recurrence observed in any patient.

  Conclusions  ESD and EFR are safe and effective in the treatment of gastric submucosal tumors with less trauma and complications.