Abstract:
Objective : To explore the clinicopathologic features of inflammatory myofibroblastic tumor (IMFT) of the urinary bladder.
Methods : Tissues from 3 cases of IMFT were assessed with immunohistochemistry and the clinical data were analyzed.
Results : Among the 3 patients, there were 2 females and 1 male. The average age of these 3 patients was 34 years (range from 23 to 47 years). The most common clinical manifestation was hematuria. The tumors were composed of fascicles of spindle and stellate cells in a myxoid stroma, associated with mixed inflammatory cells. Immunohistochemically, tumor cells were positive for ALK, SMA and vimentin, partially positive for AE1/AE3, but negative for CD34, CD31, MyoD1, S-100 and CD117. Follow-up was available for all 3 patients and none of them had local recurrence.
Conclusion : IMFT of urinary bladder is rare but it is a potential neoplasm of intermediate malignancy. IMFT must be differentiated from leiomyosarcoma, sarcomatoid urothelial carcinoma, solitary fibrous tumor and myxofibrosarcoma.