Abstract: Objective : To discuss the effect of stereotactic radiotherapy (SRT) combined with percutaneous ethanol injection therapy (PEIT) for small hepatocarcinoma. Methods : Fifty-three cases of small hepatocarcinoma patients were divided into 3 groups. Group A included 19 patients who underwent PEIT after fractional stereotactic radiotherapy (FSRT). Group B included 14 patients who received FSRT alone. Group C included 20 patients who underwent PEIT alone. Results : All patients took CT examination at 3 months after treatment. The complete remission rates in group A, B and C were 57.9%, 42.9% and 30.0%, respectively. The 2and 3-year survival rates were 73.7% and 57.9% in group A, 50.0% and 35.7% in group B, and 73.7% and 57.9% in group C. Group A had higher complete remission rate, 2and 3-year survival rates (P <0.05). Conclusion : FSRT combined with PEIT is an effective treatment for small hepatocarcinoma.