董洪敏, 金风, 吴伟莉, 陈海霞, 黄薇, 刘兴祥. 脑胶质瘤术后放疗合并榄香烯同步治疗的疗效观察[J]. 中国肿瘤临床, 2008, 35(15): 858-860.
引用本文: 董洪敏, 金风, 吴伟莉, 陈海霞, 黄薇, 刘兴祥. 脑胶质瘤术后放疗合并榄香烯同步治疗的疗效观察[J]. 中国肿瘤临床, 2008, 35(15): 858-860.
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DONG Hongmin, JIN Feng, WU Wei Li, CHEN Haixia, HUANG Wei, LIU Xingxiang. Postoperative Radiotherapy Combined with Elemene for Brain Glioma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(15): 858-860.
Citation: DONG Hongmin, JIN Feng, WU Wei Li, CHEN Haixia, HUANG Wei, LIU Xingxiang. Postoperative Radiotherapy Combined with Elemene for Brain Glioma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(15): 858-860.
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脑胶质瘤术后放疗合并榄香烯同步治疗的疗效观察

Postoperative Radiotherapy Combined with Elemene for Brain Glioma

    摘要
  • 摘要: 目的 :探讨榄香烯与放疗同步治疗脑胶质瘤的临床疗效。 方法 :总结分析我科2002年1月至2004年12月间,榄香烯锁骨下静脉滴注与放疗同步治疗脑胶质瘤术后残留32例(治疗组)的疗效。放疗采用6MV-X线,肿瘤DT5056Gy/2528F,每日一次,每周5次。榄香烯乳锁骨下静脉滴注600mg/日,于放疗第1日开始至放疗疗程结束,总量21~25.2g。对照组28例予单纯放射治疗,方法同前。 结果 :1)治疗组完全缓解(CR)4例,部分缓解(PR)21例,治疗有效率(CR+PR)为78.1%(25/32);对照组CR2例,PR12例,CR+PR50.0%(14/28),两组治疗有效率比较有显著性差异(P<0.05)。2)治疗组与对照组1、2、3年生存率分别为81.0%、57.8%、34.0%与63.6%、26.2%、18.7%,治疗组明显高于对照组(P<0.05)。3)本组榄香烯治疗副作用主要表现为发热,发生率12.5%(4/32);两组患者治疗血液学毒性相似,治疗中、后脑水肿发生率相似。 结论 :榄香烯锁骨下静脉滴注与放疗同步治疗脑胶质瘤疗效明显,较脑胶质瘤术后单纯放疗提高了生存期,未增加放疗毒副反应,值得进一步探讨。

     

    Abstract: Objective : To investigate the effect of Elemene combined with radiotherapy for brain glioma. Methods : From January 2002 to December 2004, 32 patients with brain glioma who had residual tumor after surgery and received Elemene combined with radiotherapy were retrospectively reviewed. These patients received a dose of 50-56Gy/25-28F/5-6 weeks by 6MV-X ray, 1f/d, 5 times a week. Concurrent with radiotherapy, Elemene was administered at 600mg/d intravenously (via subclavical vein). The control group (28 cases) were treated with radiotherapy alone. Results : In the Elemene plus radiotherapy group, 4 cases achieved complete response (CR), 21 cases had partial response (PR). The total response rate (CR+PR) was 78.1%. While in the control group, 2 cases had CR, 12 cases had PR, and the total response rate (CR+PR) was 50.0% (P < 0.05). The 1-, 2-, and 3-year survival rates were 81.0 %, 57.8%, and 34.0% in the Elemene plus radiotherapy group and 63.6 %, 26.2%, and 18.7% in the control group. The side effect of Elemene was fever, and the side effect of radiotherapy were similar in both groups. Conclusion : Elemene combined with radiotherapy is effective for brain glioma and can achieve a longer survival time, without increasing the side effects of radiotherapy.

     

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