Abstract: Objective : To investigate the diagnosis and surgical treatment of cardiac pheochromocytoma. Methods : We analyzed the clinical data of 3 cases (2 males and 1 female) of cardiac pheochromocytoma who were 17, 19 and 35 years old. They all presented with headache, sweating, palpitation and hypertension. The preoperative 24-hour urinary catecholamine excretion was significantly raised. Masses were observed on CT, MRI, coronary arterography and so on. All 3 patients had positive results with Te-99m-Otretide Scintigraphy (HTOC) and underwent orthotopic excision of tumors under cardiopulmonary bypass. Results : The quality of life for these 3 patients was satisfactory during follow-up (28-48 months). Instances of headache, sweating, palpitation and hypertension decreased. Postoperative pathology confirmed the diagnosis of cardiac pheochromocytoma. Follow-up revealed that the 17-year old patient had positive results with HTOC, and the 35-year old patient had a higher level of 24-hour urinary catecholamine excretion than normal. Conclusion : Cardiac pheochromocytoma is a rare tumor and its diagnosis and surgical treatment are rather difficult and complex. Surgical excision is an effective treatment for cardiac pheochromocytoma and heart transplantation may be a therapeutic option in selected patients when the tumor cannot be resected.