Abstract: Objective : To evaluate of the expression of the MHC class Ⅰ antigen presentation-associated proteinsCNX, HSP90 and GRP94, and to investigate their correlation with HPV16 infection in cervicitis and cervicalcancer in patients of Urghur and Han nationality. Methods : We used immunohistochemistry to detect the ex-pression of CNX, HSP90 and GRP 94 proteins in 66 cervicitis tissues from 39 Han and 27 Urghur women and92 cervical cancer tissues from 30 Han and 62 Urghur women. Using specific primers for HPV16, PCR wasemployed to detect HPV16 infection in these tissues. Results : The overall expression rate of CNX in cervicalcancer tissues (67.39 %) in both ethnic groups was lower than that in cervicitis tissues (86.36 %) (P<0.05).The expression rate of CNX in the cervicitis tissues from Urghur women was higher than that in Han women(100% vs. 76.92%, P<0.05). The expression of HSP90 and GRP94 in the cervical cancer tissues from bothUrghur and Han women was higher than that in the cervicitis tissues (P<0.05). The expression rate of HSP90in the cervical cancer tissues was lower in Urghur patients than in Han patients (P<0.05). The infection rate ofHPV16 in cervicitis and cervical cancer in Urghur women was higher than that in Han women (P<0.05). A cor-relation was found between HSP90 expression and GRP94 expression in cervical cancer in Urghur patients(r=0.249, P<0.05) .The expression of HSP90 was positively correlated with HPV16 infection in cervical cancerin both ethnic groups (r=0.361, P<0.05). Conclusion : Detection of CNX, HSP90, and GRP94 protein expres-sion along with screening for HPV16 infection may improve the diagnosis of cervical cancer.