刘伏香, 李华淑, 莫朝霞. 术前介入治疗对ⅠB2~ⅡB期宫颈癌的疗效分析[J]. 中国肿瘤临床, 2008, 35(20): 1165-1167,1174.
引用本文: 刘伏香, 李华淑, 莫朝霞. 术前介入治疗对ⅠB2~ⅡB期宫颈癌的疗效分析[J]. 中国肿瘤临床, 2008, 35(20): 1165-1167,1174.
LIU Fu-xiang, LI Hua-shu, MO Zhao-xia. The Effects of Preoperative Interventional Therapy on Stage ⅠB2-ⅡB Cervical Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(20): 1165-1167,1174.
Citation: LIU Fu-xiang, LI Hua-shu, MO Zhao-xia. The Effects of Preoperative Interventional Therapy on Stage ⅠB2-ⅡB Cervical Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(20): 1165-1167,1174.

术前介入治疗对ⅠB2~ⅡB期宫颈癌的疗效分析

The Effects of Preoperative Interventional Therapy on Stage ⅠB2-ⅡB Cervical Carcinoma

  • 摘要: 目的: 探讨术前介入治疗(动脉灌注化疗栓塞)对ⅠB2~ⅡB期宫颈癌患者的近期与远期疗效。 方法: 将1997年1月至2002年1月期间,解放军第169中心医院143例ⅠB2~ⅡB期宫颈癌患者分为观察组与对照组。观察组86例,采用术前介入治疗、手术及放射综合治疗;对照组57例,手术及放射综合治疗。观察介入治疗后不良反应、治疗前后癌灶局部情况及病理检查变化;比较两组的术中情况及术后的生存率及复发率。 结果: 术前介入治疗不良反应少,ⅠB2~ⅡB期宫颈癌总有效率为93.0%,可缩小肿瘤的体积,使患者临床分期及癌细胞的分级逆转;对照组术中出血量为615.87±108.35ml,观察组术中的出血量为395.06±84.70m(P<0.05);对照组手术时间为4.61±0.62h,观察组为3.82±0.53h(P<0.05);对照组与观察组2年生存率分别为87.7%和93.0%(P>0.05),而对照组与观察组5年生存率分别为63.2%和83.7%(P<0.05);对照组与观察组2、5年内复发率分别为24.6%、10.5%和43.9%、26.7%(P<0.05)。 结论: 术前介入治疗能为宫颈癌患者进行根治手术创造条件,降低术后复发,改善预后,是一种疗效显著的治疗方法。

     

    Abstract: Objective : To investigate the short-term and long-term clinical efficacy of preoperative interventional ther-apy (intraarterial chemoembolization) on stage ⅠB2-ⅡB cervical cancer. Methods : From January 1997 to Jan-uary 2002, 143 patients with stage ⅠB2 -ⅡB cervical cancer were enrolled and randomly divided into thestudy group and the control group. Patients in the study group (n=86) were treated with preoperative interven-tional therapy, surgical therapy and postoperative radiotherapy. Patients in the control group (n=57) receivedsurgical therapy and postoperative radiotherapy. Local lesions, pathological features, patient conditions dur-ing surgery, and the postoperative survival and recurrence rates were compared between the two groups. Re-sults : The overall effective rate of interventional therapy for stage IB2-IIB cervical cancer was 93.02%. Inter-ventional therapy reduced tumor size and decreased the clinical stage and grade of carcinoma. The averageintraoperative blood loss was 615.87 ± 108.35 ml in the control group and 395.06 ± 84.70 ml in the studygroup (P<0.05). The duration of surgery was 4.61 ± 0.62 hours in the control group and 3.82±0.53 hours inthe study group (P<0.05). The 2-year survival rate was 87.7% in the control group and 93% in the study group(P>0.05). The 5-year survival rate was 63.2% in the control group and 83.7% in the study group (P<0.05). The2- and 5-year recurrence rates were 24.6% and 10.5% in the control group and 43.9% and 26.7% in the studygroup (P<0.05). Conclusion : For patients with IB2-IIB stage cervical cancer, preoperative interventional thera-py can help ensure successful radical surgery, reduce the postoperative recurrence rate, and improve progno-sis.

     

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