Abstract:
Objective : To investigate the short-term and long-term clinical efficacy of preoperative interventional ther-apy (intraarterial chemoembolization) on stage ⅠB
2-ⅡB cervical cancer.
Methods : From January 1997 to Jan-uary 2002, 143 patients with stage ⅠB
2 -ⅡB cervical cancer were enrolled and randomly divided into thestudy group and the control group. Patients in the study group (
n=86) were treated with preoperative interven-tional therapy, surgical therapy and postoperative radiotherapy. Patients in the control group (
n=57) receivedsurgical therapy and postoperative radiotherapy. Local lesions, pathological features, patient conditions dur-ing surgery, and the postoperative survival and recurrence rates were compared between the two groups.
Re-sults : The overall effective rate of interventional therapy for stage IB2-IIB cervical cancer was 93.02%. Inter-ventional therapy reduced tumor size and decreased the clinical stage and grade of carcinoma. The averageintraoperative blood loss was 615.87 ± 108.35 ml in the control group and 395.06 ± 84.70 ml in the studygroup (
P<0.05). The duration of surgery was 4.61 ± 0.62 hours in the control group and 3.82±0.53 hours inthe study group (
P<0.05). The 2-year survival rate was 87.7% in the control group and 93% in the study group(
P>0.05). The 5-year survival rate was 63.2% in the control group and 83.7% in the study group (
P<0.05). The2- and 5-year recurrence rates were 24.6% and 10.5% in the control group and 43.9% and 26.7% in the studygroup (
P<0.05).
Conclusion : For patients with IB2-IIB stage cervical cancer, preoperative interventional thera-py can help ensure successful radical surgery, reduce the postoperative recurrence rate, and improve progno-sis.