Abstract: Unsuspected gallbladder carcinoma (UGC) is defined as carcinoma of the gallbladder firstly diagnosedat the histological examination of the resected gallbladder. More and more cholecystectomies have beenlaparoscopically performed all over the world. The incidence of UGC becomes much higher. In this article wediscussed the prognostic factors and the management of UGC, in an effort of providing suggestions to thetreatment of UGC. Based on literatures, we compared the effect of different surgical procedures on UGC ofdifferent T stage and analyzed the prognostic factors. Tumor infiltrative depth, lymph node state,intraoperative bile leakage, excision extent, and second radical excision were the prognostic factors of UGC,among which tumor infiltrative depth is the most important factor. For control of UGC and improvement of itsprognosis, we should pay close attention to the risk factors of UGC, standardize the implication of LC, checkthe dissected gallbladder during surgery, and turn to OC in time or make second radical excision early afterLC.