Abstract: Objective : To evaluate the prognostic value of histopathologic factors and criteria for recipient selection inpatients with hepatocellular carcinoma after liver transplantation (LT). Methods : A retrospective study was carriedout in 204 HCC patients after liver transplantation. Survival rates were analyzed with the actuarial life-table method.Multivariate and univariate Cox proportional hazards model were used to investigate the correlation betweenhistopathologic factors and survival time. Kaplan-Meier and Log-rank tests were used to explore the correlationbetween survival rates and histopathologic factors. Results : The follow-up duration ranged from 6 to 62 months.The mortality was 33.1%. The recurrence rate was 32.4%. The 1-, 2-, 3-, 4- and 5-year cumulative survival rateswere 82.2%, 65.0%, 52.3%, 46.9%, and 42.0%, respectively. Through a COX model analysis, univariate analysesrevealed that alpha fetoprotein, tumor size, envelope invasion, Eggels classification, microvascular invasion,invasion of portal vein, Edmonson grade, TNM staging and scores of Model of end stage liver disease (MELD)were significantly related with survival (P<0.05). In a multivariate COX model, alpha fetoprotein (RR: 1.542, P=0.002), Eggels classification (RR: 1.617, P=0.003), microvascular invasion (RR: 2.643, P<0.001) and Edmonsongrade (RR: 2.181, P=0.009) were independent prognostic factors. Conclusion : Alpha fetoprotein, Eggels classi-fication, microvascular invasion and Edmonson grade were important prognostic factors. A strict selection ofrecipients is benefitial for long term survival after transplantation.