Abstract: Objective : To investigate the therapeutic value of micro-injury technology of endoscopy for the treatmentof early cardia cancer and precancerous lesions. Methods : Endoscopic mucosal resection (EMR) and Argonplasma coagulation (APC) were performed on 108 lesions of early cardia cancer or precancerous lesions in104 patients in a high incidence area. The distribution of sites, treatment indication and results of follow-upwere analyzed. Results : Seventy-one percent of these lesions were located in 12 to 3 clock sites of cardia,and 25.9% were in other clock sites of cardia, with a significant difference (P<0.01). Pre- and post-EMR patho-logical comparison showed that one lesion (1/4) of moderate dysplasia identified by pre-operative pathologywas confirmed as intramucosal carcinoma after EMR. Three lesions (3/36) of severe dysplasia identified bypre-operative pathology were confirmed as intramucosal carcinoma, and one lesion (1/36) was confirmed asearly invasive carcinoma after EMR. One lesion (1/10) of intramucosal carcinoma was diagnosed as early in-vasive carcinoma after EMR. Two lesions were diagnosed as early invasive carcinoma according topost-pathology and other leisons were successfully treated in EMR group. The success rate of EMR was96%. The success rate of APC was 83.3% for intramucosal carcinoma, and 100% for precancerous lesions.The main complications included hemorrhage in 2 cases (4.0%) in EMR group and 1 case (1.7%) in APCgroup. Perforation and stenosis were not observed., the 3- and 5-year survival rates were 100% and 92.3%in the EMR group and 100% in the APC group. Conclusion : Early cardia cancer and precancerous lesions are mainly located on 12 to 3 clock sites of cardia, indicating that close observation of these sites would improvethe detection rate of cardia lesions. Sufficient submucosal injection is an important measure to avoid the com-plications of endoscopic treatment. Treatment with EMR and APC is simple, accurate, efficient and safe, andis very easy to apply.